摘要
目的通过职业性砷接触工人尿形态砷水平测定分析,探究其与健康效应的相关性。方法于2021年11月,分别选择云南省某有色金属冶炼厂的95名接触砷及其无机化合物的工人和31名行政人员作为接触组和对照组,进行尿形态砷、血液肿瘤标志物、肝功能检测,并采用微核试验分析染色体损伤,分析尿形态砷与健康效应的相关性。结果与对照组比较,接触组班末尿三价无机砷(iAs3+)、五价无机砷(iAs5+)、无机砷(iAs=∑iAs3++iAs5+)、一甲基砷(MMA)、二甲基砷(DMA)和尿砷(∑iAs+MMA+DMA)浓度均更高(P<0.05);两组间血液肿瘤标志物和肝功能指标比较,差异均无统计学意义(P>0.05);与对照组比较,接触组外周血微核率和细胞微核率均明显升高(P<0.05)。接触组尿砷、iAs5+、无机砷、DMA与外周血微核率呈正相关(rs=0.48、0.34、0.37、0.23,P<0.05),尿砷、iAs5+、DMA与外周血微核细胞率呈正相关(rs=0.48、0.34、0.26,P<0.05)。结论职业性砷接触工人尿中不同价态砷与健康异常效应具有明显相关性,应加强职业性砷接触工人尿形态砷的检测工作,以更好地保护工人健康。
Objective To explore the correlation between urinary arsenic and health effects through the determination and analysis of urinary arsenic levels in occupational arsenic exposed workers.Methods In November 2021,95 workers exposed to arsenic and its inorganic compounds and 31 administrative personnel from a non-ferrous metal smelter in Yunnan Province were selected as the contact group and control group,respectively.Urine forms of arsenic,blood tumor markers,liver function were detected,and micronucleus test was used to analyze the chromosome damage.The correlation between urine forms of arsenic and health effects were analyzed.Results Compared with the control group,the concentrations of urinary trivalent inorganic arsenic(iAs3+),pentavalent inorganic arsenic(iAs5+),inorganic arsenic(iAs=∑iAs3++iAs5+),monomethyl arsenic(MMA),dimethyl arsenic(DMA)and urinary arsenic(∑iAs+MMA+DMA)at the end of class in contact group were higher(P<0.05).There was no statistically significant difference in blood tumor markers and liver function indicators between the two groups(P>0.05).Compared with the control group,the peripheral blood micronucleus rate and cell micronucleus rate in the contact group were significantly increased(P<0.05).The urinary arsenic,iAs5+,inorganic arsenic and DMA were positively correlated with peripheral blood micronucleus rate in contact group(rs=0.48,0.34,0.37,0.23,P<0.05),and the urinary arsenic,iAs5+,DMA were positively correlated with peripheral blood micronucleus rate(rs=0.48,0.34,0.26,P<0.05).Conclusion There is a significant correlation between different valence states of arsenic in the urine and abnormal health effects of occupational arsenic exposed workers.It is necessary to strengthen the detection of arsenic species in the urine of occupational arsenic exposed workers to better protect their health.
作者
邱炜
丑欣
沈悦
马鲲鹏
孙道远
闵珍
Qiu Wei;Chou Xin;Shen Yue;Ma Kunpeng;Sun Daoyuan;Min Zhen(Occupational Medicine,The Third People's Hospital of Yunnan Province,Kunming 650011,China;Physical and Chemical Laboratory of Poisoning Department,Shanghai Pulmonary Hospital Affiliated to Tongji University,Shanghai 200433,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2024年第2期102-107,共6页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
中国疾病预防控制中心化学污染与健康安全重点实验室开放基金(2023CDCKL01)
上海市2023年度"科技行动创新计划"国内科技合作项目(23015820200)
中国疾病预防控制中心职业卫生与中毒控制职业接触限值前期研究项目(20210203)
云南省孙道远专家工作站。
关键词
职业暴露
砷甲基化
无机砷
一甲基砷
二甲基砷
尿形态砷
Occupational exposure
Arsenic methylation
Inorganic arsenic
Monomethyl arsonic
Dimethyl arsinic
Arsenic species
