摘要
目的 探讨丁苯酞联合依达拉奉治疗对老年脑梗死患者神经功能、颈动脉内中膜厚度、斑块面积的影响。方法 选取自2021年9月至2022年9月收治的126例急性脑梗死患者为研究对象,随机分为常规组(n=66)与联合组(n=60)。两组均给予常规脑梗死基础治疗,联合组在常规治疗基础上增加丁苯酞联合依达拉奉治疗,常规组增加依达拉奉治疗。观察治疗前,后两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)、改良RANKIN量表(mRS)、Barthel指数(BI)、颈动脉血管内膜中层厚度(CIMT)及内膜斑块面积。结果 治疗后,联合组NIHSS评分及mRS评分均低于常规组及本组治疗前;常规组NIHSS评分及mRS评分低于本组治疗前,差异有统计学意义(P<0.05)。治疗后,两组BI指数均高于本组治疗前,且联合组BI指数高于常规组,差异有统计学意义(P<0.05)。治疗后,联合组治疗总有效率高于常规组,联合组CIMT、斑块面积均低于常规组及本组治疗前,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 对于老年急性脑梗死患者,在常规治疗基础上增加丁苯酞与依达拉奉联合治疗能通过降低CIMT,减轻动脉粥样硬化程度,有效改善脑组织血供不足,从而恢复神经功能。
Objective To study the effects of butylphthalide combined with edaravone on neurological function,carotid intima⁃media thickness,and plaque area in elderly patients with cerebral infarction.Methods A total of 126 patients with acute cerebral infarction treated in our hospital from September 2021 to September 2022 were enrolled,and randomly divided into conventional group(n=66)and combined group(n=60).Both groups received the routine treatment,based on this,combined group received the butylphthalide combined with edaravone,while conventional group only received the edaravone.Then the clinical efficacy,National Institute of Health Stroke Scale(NIHSS),modified Rankin Scale(mRS),Barthel Index(BI),carotid intima⁃media thickness(CIMT),and intimal plaque area were compared between groups.Results After treatment,NIHSS scores and mRS Scores in the combined group were lower than those in the conventional group and before treatment.NIHSS scores and mRS Scores in the conventional group were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,BI index of both groups was higher than that before treatment,and BI index of combination group was higher than that of conventional group,the difference was statistically sig⁃nificant(P<0.05).After treatment,the total effective rate of the combined group was higher than that of the conventional group,and the CIMT and plaque area of the combined group were lower than those of the conventional group and before treatment(P<0.05),with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Application of routine treatment in combination with butylphthalide and edaravone for elderly pa⁃tients with acute cerebral infarction can effectively reduce the CIMT,alleviate the atherosclerosis degree,improve the blood supply of brain tissue,and restore the neurological function.
作者
刘蕊
官彬
杨剑波
LIU Rui;GUAN Bin;YANG Jian-bo(Department of Neurology,First Affiliated Hospital of Xi′an Jiaotong University Medical College,Xi′an 710061,China)
出处
《创伤与急危重病医学》
2023年第6期390-393,共4页
Trauma and Critical Care Medicine
基金
陕西省社会发展科技攻关项目(2016SF-053)。
关键词
丁苯酞
依达拉奉
急性脑梗死
神经功能
颈动脉结构
Butylphthalide
Edaravone
Acute cerebral infarction
Neurological function
Carotid anatomy
