摘要
目的分析血清降钙素原(PCT)、血清淀粉样蛋白A(SAA)及白细胞介素-6(IL-6)水平对肝硬化合并腹水感染的诊断价值。方法选取2021年1月至2022年12月收治的109例肝硬化患者为研究对象,其中82例疑似存在腹水感染(感染组),27例不存在腹水感染(未感染组)。所有患者入院后均行血清PCT、SAA及IL-6水平检测。比较感染组和非感染组的检测结果及PCT、SAA、IL-6单一和联合检测对肝硬化合并腹水感染的诊断效能。结果感染组的PCT、SAA、IL-6水平均高于未感染组,差异具有统计学意义(P<0.05)。PCT、SAA、IL-6单一检测对肝硬化合并腹水感染的诊断准确度、灵敏度比较,差异无统计学意义(P>0.05);PCT、SAA、IL-6单一及联合检测对肝硬化合并腹水感染的诊断特异度比较,差异无统计学意义(P>0.05);联合检测对肝硬化合并腹水感染的诊断准确度、灵敏度高于PCT、SAA、IL-6单一检测,差异具有统计学意义(P<0.05)。结论血清PCT、SAA及IL-6联合检测对肝硬化合并腹水感染的诊断价值较高,可为疾病的早期治疗提供科学依据。
Objective To analyze the diagnostic value of serum procalcitonin(PCT),serum amyloid A protein(SAA)and interleukin-6(IL-6)levels for liver cirrhosis complicated with ascites infection.Methods A total of 109 patients with liver cirrhosis admitted from January 2021 to December 2022 were selected as the study objects,including 82 patients with suspected ascites infection(infection group)and 27 patients without ascites infection(non-infection group).Then serum PCT,SAA and IL-6 levels were detected in all patients after admission.The detection results of the infection group and the non-infection group and the diagnostic efficacy of single and combined detection of PCT,SAA and IL-6 for liver cirrhosis complicated with ascites infection were compared.Results The levels of PCT,SAA and IL-6 in the infected group were higher than those in the non-infection group,and the differences were statistically significant(P<0.05).There were no significant differences in the diagnostic accuracy and sensitivity of PCT,SAA and IL-6 single detection for liver cirrhosis complicated with ascites infection(P>0.05);there was no significant difference in the diagnostic specificity of PCT,SAA,IL-6 single and combined detection for liver cirrhosis complicated with ascites infection(P>0.05);the diagnostic accuracy and sensitivity of combined detection for cirrhosis complicated with ascites infection were higher than those of PCT,SAA and IL-6 single detection,and the differences were statistically significant(P<0.05).Conclusion The combined detection of serum PCT,SAA and IL-6 is of high value in the diagnosis of liver cirrhosis complicated with ascites infection,which can provide scientific basis for early treatment of the disease.
作者
朱婷
董青利
ZHU Ting;DONG Qingli(Hepatology Department,Xi'an Eighth Hospital,Xi'an 710061;Clinical Laboratory Department,Weinan First Hospital,Weinan 714000,China)
出处
《临床医学研究与实践》
2024年第8期89-92,共4页
Clinical Research and Practice
