摘要
随着生殖免疫学的发展研究,免疫功能异常成为引起复发性流产(RSA)的重要原因之一。自身免疫性疾病分为器官特异性、系统性自身免疫性疾病两种表现形式,其中系统性自身免疫性疾病是以机体淋巴细胞的激活或自身高滴度抗体的产生导致组织、器官损伤为主要特点的免疫紊乱性疾病,是导致病理妊娠(RSA、胎儿死亡、早产、胎盘功能不全等)发生的重要原因之一。目前引起RSA常见的自身免疫性疾病以抗磷脂综合征(APS)、系统性红斑狼疮(SLE)、自身免疫性甲状腺疾病(AITD)、类风湿性关节炎(RA)、未分化结缔组织病(UCTD)、干燥综合征(SS)为主。本文就RSA合并自身免疫性疾病做一阐述,以丰富RSA临床诊疗方案,减轻患者及家庭的心理负担。
With the development of reproductive immunology research,immune dysfunction has become one of the important causes of recurrent spontaneous abortion(RSA).Autoimmune diseases are divided into organ-specific and systemic autoimmune diseases,systemic autoimmune diseases are immune disorders characterized by tissue and organ damage caused by the activation of lymphocytes or the production of high-titer autoantibodies,it is one of the important causes of pathological pregnancy(RSA,fetal death,premature delivery,placental insufficiency,etc.).At present,the common autoimmune diseases causing RSA are mainly antiphospholipid syndrome(APS),systemic lupus erythematosus(SLE),autoimmune thyroid disease(AITD),rheumatoid arthritis(RA),undifferentiated connective tissue disease(UCTD)and sicca syndrome(SS).This article reviews RSA combined with autoimmune diseases to enrich the clinical diagnosis and treatment of RSA and reduce the psychological burden of patients and families.
作者
孙晓娜
许红英
SUN Xiaona;XU Hongying(Hubei University of Chinese Medicine,Wuhan 430065;Jingzhou Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine,Jingzhou 434000,China)
出处
《临床医学研究与实践》
2024年第8期195-198,共4页
Clinical Research and Practice
关键词
自身免疫性疾病
复发性流产
免疫紊乱
autoimmune disease
recurrent spontaneous abortion
immunologic derangement
