摘要
目的探究自制纸尿裤冰帽模拟亚低温疗法治疗新生儿重度窒息的疗效和安全性。方法40例新生儿重度窒息患儿,采用随机数字表法分成对照组和试验组,各20例。对照组给予常规综合治疗,试验组在常规治疗基础上应用自制纸尿裤冰帽模拟亚低温疗法治疗。比较两组治疗前后的生化指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)、肌酐(Cr)]及血清神经元特异性烯醇化酶(NSE)水平,治疗前及出生后不同时间的新生儿神经行为测定(NBNA)评分,不良事件发生率。结果治疗后,两组ALT、AST、BUN、Cr均低于本组治疗前,且试验组ALT(11.11±1.02)U/L、AST(33.24±2.48)U/L、BUN(4.35±0.34)mmol/L、Cr(55.24±2.15)μmol/L均低于对照组的(15.36±1.24)U/L、(40.64±3.24)U/L、(6.34±0.54)mmol/L、(61.36±2.64)μmol/L(P<0.05)。治疗后,两组NSE低于本组治疗前,且试验组NSE(8.01±0.34)μg/L低于对照组的(12.22±0.34)μg/L(P<0.05)。出生后7、14、28 d,两组NBNA评分均高于本组治疗前,且试验组NBNA评分分别为(37.24±1.22)、(38.11±1.11)、(39.01±0.28)分,均高于对照组的(35.21±1.01)、(36.04±1.05)、(37.24±0.34)分(P<0.05)。试验组不良事件发生率5.00%低于对照组的30.00%(P<0.05)。结论自制纸尿裤冰帽模拟亚低温疗法治疗新生儿重度窒息疗效确切,安全性高。
Objective To explore the efficacy and safety of self-made diaper ice cap simulated mild hypothermia therapy in the treatment of severe neonatal asphyxia.Methods 40 children with severe asphyxia were divided into a control group and a test group according to random numerical table,with 20 cases in each group.The control group was given routine comprehensive treatment,and the test group was given self-made diaper ice cap simulated mild hypothermia therapy based on routine treatment.Both groups were compared in terms of biochemical indicators[alanine aminotransferase(ALT),aspartate transaminase(AST),blood urea nitrogen(BUN),creatinine(Cr)]and serum neuron-specific enolase(NSE)levels,neonatal behavior neurological assay(NBNA)scores before treatment and at different times after birth,and the incidence of adverse events.Results After treatment,ALT,AST,BUN and Cr in both groups were lower than those before treatment;the test group had ALT of(11.11±1.02)U/L,AST of(33.24±2.48)U/L,BUN of(4.35±0.34)mmol/L and Cr of(55.24±2.15)μmol/L,which were lower than(15.36±1.24)U/L,(40.64±3.24)U/L,(6.34±0.54)mmol/L and(61.36±2.64)μmol/L in the control group(P<0.05).After treatment,NSE in both groups was lower than that before treatment,and NSE of(8.01±0.34)μg/L in the test group was lower than(12.22±0.34)μg/L in the control group(P<0.05).At 7,14 and 28 d after birth,NBNA scores in both groups were higher than those before treatment;NBNA scores in the test group were(37.24±1.22),(38.11±1.11)and(39.01±0.28)points,which were higher than(35.21±1.01),(36.04±1.05)and(37.24±0.34)points in the control group(P<0.05).The incidence of adverse events in the test group was 5.00%,which was lower than 30.00%in the control group(P<0.05).Conclusion Self-made diaper ice cap simulated mild hypothermia therapy has definite effect and high safety in the treatment of severe neonatal asphyxia.
作者
冯晓虹
FENG Xiao-hong(Enping City People's Hospital,Jiangmen 529400,China)
出处
《中国现代药物应用》
2024年第4期55-58,共4页
Chinese Journal of Modern Drug Application
基金
2022年度江门市卫生健康局科研项目(项目编号:22A125),项目名称:自制纸尿裤冰帽模拟亚低温疗法治疗新生儿重度窒息的疗效和安全性。
关键词
新生儿窒息
自制纸尿裤冰帽
亚低温疗法
Neonatal asphyxia
Self-made diaper ice cap
Mild hypothermia therapy
