摘要
目的探讨早期生长反应因子(EGR-1)和基质金属蛋白酶-2(MMP-2)在早期自然流产患者绒毛中的表达及临床意义。方法采用RT-PCR和Westernblot检测20例早期自然流产患者(流产组)和20例正常早孕人工流产(对照组)绒毛组织中EGR-1和MMP-2的表达情况。结果流产组中EGR-1、MMP-2 mRNA和蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。结论EGR-1和MMP-2在早孕绒毛组织中表达异常可能参与早期妊娠失败的发生。
Objective To investigate the expression and clinical significance of early growth response factor(EGR-1)and matrix metalloproteinase-2(MMP-2)in the villi of patients with early spontaneous abortion.Methods RT-PCR and Westernblot were used to detect the expression of EGR-1 and MMP-2 in the chorionic villus tissues of 20 patients with early spontaneous abortion(abortion group)and 20 normal early pregnancy abortions(control group).Results The levels of EGR-1,MMP-2 mRNA and protein in the abortion group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Abnormal expression of EGR-1 and MMP-2 in early pregnancy chorionic tissue may be involved in the development of early pregnancy failure.
作者
丁书军
黄丽霞
熊雪
黄宁
DING Shu-jun;HUANG Li-xia;XIONG Xue;HUANG Ning(Clinical Laboratory,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China;Medical Genetics Centre,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)
出处
《实用临床医学（江西）》
CAS
2024年第1期40-42,73,共4页
Practical Clinical Medicine
基金
江西省卫健委科技计划(202130770)
江西省中医药管理局科技计划(2020B0343)
江西省卫健委科技计划(202211059)
江西省科技厅应用研究培育计划(20181BBG78005)。
