摘要
目的探讨优甲乐治疗妊娠期亚临床甲减(SCH)患者的效果。方法选取2021年1月至2022年6月于萍乡市上栗县妇幼保健院就诊的84例妊娠期SCH患者,采用随机数字表法将其分为对照组和研究组,各42例。对照组予以甲状腺片治疗,研究组予以优甲乐治疗。比较2组疗效、妊娠结局、治疗前后的血清同型半胱氨酸(Hcy)与叶酸(FA)水平和甲状腺功能指标水平[促甲状腺激素(TSH)、游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)]及不良反应发生情况。结果研究组治疗总有效率高于对照组,早产率、剖宫产率、流产率低于对照组(均P<0.05);治疗6周后,研究组血清Hcy、TSH、水平均较对照显著降低,而FA、FT3、FT4水平较对照组显著提高(均P<0.001);2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论妊娠期SCH患者采用优甲乐治疗效果较好,可改善妊娠结局,调节血清Hcy与FA水平,提高甲状腺功能,且安全性好。
Objective To investigate the effects of Unimethylate on pregnancy outcomes and thyroid function in patients with subclinical hypothyroidism(SCH)in pregnancy.Methods A total of 84 SCH patients in pregnancy who attended Shangli County Maternal and Child Health Hospital from January 2021 to June 2022 were selected,and they were divided into the control group and the study group according to the method of randomized numerical table,with 42 cases in each group.The control group was treated with thyroid tablets,and the study group was treated with Unimethylate.The efficacy,pregnancy outcome,serum homocysteine(Hcy),folic acid(FA)levels,levels of thyroid function indexes[thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)],and the occurrence of adverse reactions before and after treatment were compared between the 2 groups.Results The total effective rate of treatment in the study group was higher than that in the control group,and the rates of preterm labor,cesarean section,and miscarriage were lower than those in the control group(all P<0.05).After 6 weeks of treatment,the levels of serum Hcy and TSH were significantly lower in the study group compared to the control group,whereas the levels of FA,FT3,and FT4 were notably higher(all P<0.001).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion the treatment of SCH patients in pregnancy,Unimethylate may improve pregnancy outcome,regulate serum Hcy and FA levels,and enhance thyroid function with good safety,thereby achieving positive therapeutic effect.
作者
李霞
黎秋平
黎娇
LI Xia;LI Qiu-ping;LI Jiao(Obstetrics&Gynecology Clinic,Shangli County Maternal and Child Health Hospital,Pingxiang 337009,China;Obstetrics Inpatient Unit,Shangli County Maternal and Child Health Hospital,Pingxiang 337009,China)
出处
《实用临床医学（江西）》
CAS
2024年第1期46-49,共4页
Practical Clinical Medicine
关键词
妊娠期亚临床甲减
优甲乐
妊娠结局
甲状腺功能
subclinical hypothyroidism(SCH)in pregnancy
Unimethylate
pregnancy outcome
thyroid function
