摘要
白念珠菌的生物膜是相对于其悬浮生长状态而言的一种独特的生长形式,是其产生毒力或致病的关键因子,生物膜形态的白念珠菌对多种抗真菌药物表现出高度耐药,给临床治疗带来巨大挑战。对白念珠菌生物膜及其生物学特性的研究有助于感染性疾病的预防和新抗真菌药物的开发。文章综述了白念珠菌生物膜形成的4个关键阶段,即黏附、增殖、成熟、扩散以及其耐药性形成的代表性机制。
The biofilm of Candida albicans is a unique form of growth relative to its suspended growth state and is a key factor in its virulence or pathogenicity.Biofilm forms of C.albicans exhibit high resistance to multiple antifungal drugs,posing a great challenge for clinical treatment.The study of C.albicans biofilms and their biological properties contributes to the prevention of infectious diseases and the development of new antifungal drugs.This article reviews the four key stages of Candida albicans biofilm formation(i.e.,adhesion,proliferation,maturation,and diffusion),and the mechanism of antifungal resistance in C.albicans.
作者
陈婷
李璇
黄孝天
张陆兵
CHEN Ting;LI Xuan;HUANG Xiao-tian;ZHANG Lu-bing(Jiangxi Provincial Institute of Occupational Disease Prevention and Control;Department of Microbiology,School of Basic Medical Sciences,Nanchang University,Nanchang 330006,China)
出处
《实用临床医学（江西）》
CAS
2024年第1期130-135,139,共7页
Practical Clinical Medicine
