摘要
目的探讨骨化三醇联合西那卡塞对继发性甲状旁腺功能亢进(SHPT)的治疗效果。方法选取2021年8月至2022年7月于高州市人民医院血液净化中心接受血液透析并发甲状旁腺功能亢进的患者80例,采用随机数表法分为观察组和对照组,每组各40例。在两组患者均维持透析治疗的基础上,对照组给予西那卡塞治疗,观察组给予骨化三醇联合西那卡塞治疗,两组均维持治疗6个月。比较两组临床疗效,收集治疗前后的全段甲状旁腺激素(iPTH)、甲状旁腺体积、血钙水平、血磷水平、钙磷乘积指标进行比较。结果治疗前,两组iPTH、甲状旁腺体积、血钙水平、血磷水平、钙磷乘积差异比较,差异无统计学意义(P>0.05);治疗后,观察组血钙水平高于对照组,iPTH、血磷水平均低于对照组,甲状旁腺体积小于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率优于对照组,差异有统计学意义(P<0.05)。结论骨化三醇联合西那卡塞治疗血液透析患者SHPT的临床效果显著,患者的血钙水平升高而iPTH、血磷水平均降低,甲状旁腺体积缩小,值得临床推广应用。
Objective To explore the therapeutie effect of caleitriol combined with einacalcel in the trealmenl of secondary hyperparathyroidism(SHPT).Methods A total of 80 patients with hyperparathyroidism who underwent hemodialysis at the Blood Purification Center of Gaozhou People’s Hospital from August 2021 to July 2022 were selected and divided into an observation group and a control group using a random number table method,with 40 patients in each group.Both groups of patients were treated with maintained dialysis,while the control group was treated with cinacalcet,and the observation group was treated with calcitriol combined with cinacalcet.Both groups maintained the treatment for 6 months.The therapeutic effect of the treatment in the two groups was compared,intact parathyroid hormone(iPTH),parathyroid volume,blood calcium level,blood phosphorus level,and calcium-phosphorus product before and after treatment were collected for comparison.Results Before treatment,the iPTH,parathyroid volume,blood calcium level,blood phosphorus level,and calcium-phosphorus product were compared between the two groups of patients,without statistically significant differences(P>0.05).After treatment,the blood calcium level of the observation group was higher than that of the control group,the iPTH and blood phosphorus levels were lower than those of the control group,parathyroid volume was less than that of the control group,with statistically significant differences(P<0.05).The overall treatment efficacy of the observation group was better than that of the control group,with statistically significant difference(P<0.05).Conclusion The clinical effect of calcitriol combined with cinacalcet in the treatment of SHPT in patients with hemodialysis is significant.The patient’s blood calcium level increases,while iPTH and blood phosphorus level and the parathyroid volume decrease.This treatment can be promoted and applied in clinical practice.
作者
陈翠玲
陈丽玲
汪剑云
罗玉钊
张水燕
CHEN Cuiling;CHEN Liling;WANG Jianyun;LUO Yuzhao;ZHANG Shuiyan(Department of Pharmacy,Gaozhou People’s Hospital,Guangdong,Gaozhou 525200,China;Department of Nephrology,Gaozhou People’s Hospital,Guangdong,Gaozhou 525200,China;Blood Purification Center,Gaozhou People’s Hospital,Guangdong,Gaozhou 525200,China)
出处
《中国医药科学》
2024年第4期79-83,共5页
China Medicine And Pharmacy
基金
广东省茂名市科技计划立项项目(2021593)。
