摘要
目的 探讨五龙乌附汤联合甲氨蝶呤治疗类风湿性关节炎(rheumatoid arthritis, RA)患者的疗效及对其类风湿因子水平(Rheumatoid factor, RF)、红细胞沉降率(Erythrocyte sedimentation Rate, ESR)的影响。方法 选取2021年1月—2023年1月期间郑州市中医院肾病风湿科收治的RA患者84例,按随机数字表法分为对照组和观察组,每组各42例。对照组采用甲氨蝶呤治疗,观察组在对照组基础上加用五龙乌附汤。治疗12周后,观察比较两组患者临床疗效及治疗前后中医证候积分、关节功能恢复情况、血浆指标(RF、ESR)水平、不良反应发生情况。结果 治疗后观察组临床疗效总有效率92.86%(39/42)明显高于对照组73.81%(31/42),差异有统计学意义(P<0.05)。治疗后两组患者各项中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组各项中医证候积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者关节肿胀数、关节压痛数、晨僵时间、VAS评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组关节肿胀数、关节压痛数、晨僵时间、VAS评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者RF、ESR水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组RF、ESR水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 五龙乌附汤联合甲氨蝶呤治疗RA患者疗效显著,可有效缓解其临床症状,降低RF、ESR水平,且具有较高的安全性。
Objective To investigate the therapeutic effect of Wulong Wufu Decoction combined with methotrexate in treating patients with rheumatoid arthritis(RA)and the impact on rheumatoid factor(RF)and erythrocyte sedimentation rate(ESR).Methods A total of 84 RA patients were admitted to the Department of Nephrology and Rheumatology,Zhengzhou Traditional Chinese Medicine Hospital From January 2021 to January 2023 were selected.They were randomly divided into a control group and an observation group by a random number table,with 42 in each group.The control group was given methotrexate,while the observation group was treated with Wulong Wufu Decoction in addition to methotrexate.After 12 weeks of treatment,clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,joint function recovery,plasma levels of RF and ESR,and the incidence of adverse reactions between the two groups were observed and compared.Results The total effective rate of the observation group(92.86%,39/42)was higher than that of the control group(73.81%,31/42)(P<0.05).After treatment,both groups showed a reduction in TCM syndrome scores,joint swelling count,joint tenderness count,morning stiffness duration,and VAS score(P<0.05),with the observation group exhibiting greater improvements than the control group in all these measures(P<0.05).Additionally,both groups had lowered RF and ESR after treatment(P<0.05),and the observation group had lower levels than the control group(P<0.05).The incidence of adverse reactions during treatment was not significantly different between the two groups(P>0.05).Conclusion Wulong Wufu Decoction combined with methotrexate is remarkably effective in treating RA patients,which alleviates clinical symptoms,reduces RF and ESR,demonstrating high safety.
作者
张攀科
李丹
李增变
ZHANG Pan-ke;LI Dan;LI Zeng-bian(Department of Nephrology and Rheumatology,Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou Henan 450007)
出处
《世界中西医结合杂志》
2024年第2期321-325,共5页
World Journal of Integrated Traditional and Western Medicine
基金
2021年河南省中医药拔尖人才培养项目资助[豫卫中医函(2021)15号]。
关键词
五龙乌附汤
甲氨蝶呤
类风湿性关节炎
类风湿因子
红细胞沉降率
Wulong Wufu Decoction
Methotrexate
Rheumatoid arthritis
Rheumatoid factor
Erythrocyte sedimentation rate
