摘要
目的:优化薰衣草精油(LEO)缓释固体分散体的制备工艺,并探讨体外释药模型。方法:以芳樟醇及乙酸芳樟酯为指标,建立气相-色谱质谱联用(GC-MS)技术测定溶出度的方法;选用硬脂酸、聚乙二醇6000(PEG 6000)和单硬脂酸甘油酯为辅料,优化辅料配比,采用熔融法制备LEO缓释固体分散体,考察其体外释药性能。结果:LEO缓释固体分散体的最佳处方配比为硬脂酸∶PEG 6000∶单硬脂酸甘油酯:LEO=3∶5∶1∶1,该条件下所制备的固体分散体在体外能够持续释药12 h,体外释药符合一级动力学模型。结论:所优选的处方配比工艺稳定可靠,所得缓释固体分散体能显著改善药物溶出,缓释效果令人满意。
Objective:This study mainly optimizes the preparation process of the sustained-release solid dispersion of lavender essential oil(LEO),and explores the in vitro dissolution model.Methods:Using linalool and linalyl acetate as indicators,a method for the determination of dissolution rate by gas chromatography-mass spectrometry(GC-MS)was established.Stearic acid,polyethylene glycol 6000(PEG 6000)and glyceryl monostearate were selected as excipients,and the formula proportion was optimized.The sustained-release solid dispersion of LEO was prepared by melting method,and its in vitro dissolution was investigated.Results:The optimizedformula proportion was stearic acid∶PEG 6000∶glyceryl monostearate∶LEO=3∶5∶1∶1,and the solid dispersion prepared under this condition could continuously release drug for 12 h in vitro,and the drug released in vitro conformed to the first-order kinetic model.Conclusion:The process of optimizedformula proportion was stable and reliable,the obtained sustained-release solid dispersion of LEO could significantly improve the drugdissolution,and the sustained-release effect was satisfactory.
作者
王园园
顾志荣
郭燕
毛小文
葛斌
Wang Yuanyuan;Gu Zhirong;Guo Yan;Mao Xiaowen;Ge Bin(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Pharmacy,Gansu Provincial People's Hospital,Lanzhou 730000,China)
出处
《中国野生植物资源》
CSCD
2024年第2期14-19,共6页
Chinese Wild Plant Resources
基金
兰州市科技计划项目(2021-1-76)
甘肃省中医药管理局科研项目(GZK-2019-41)
甘肃省人民医院研发攻关项目(18GSSY2-3)。
关键词
薰衣草精油
缓释固体分散体
处方配比
体外释放
硬脂酸
聚乙二醇6000
单硬脂酸甘油酯
Lavender essential oil
Sustained-release solid dispersion
Formula proportion
In vitro release
Stearic acid
Polyethylene glycol 6000
Glyceryl monostearate
