摘要
光镊技术能够实现对介观乃至微观颗粒的稳定捕获和灵活操控,是对微纳物体和单个分子施加力并观测其响应的理想操控手段。受限于光的衍射极限,传统光镊难以实现对100 nm以下物体的捕获和操控。研究者们通过开发特殊的材料和结构,将它们与传统光镊技术结合,不断突破其在小尺度物体的捕获和操控极限。本文主要综述了近年来光镊的不同技术路线在突破捕获操控极限的研究进展,以及其在物理化学领域中的应用,并对其发展和应用进行展望。
The continuous developments in physical chemistry,improved methodology,and advanced techniques have spurred interest in chemical reaction at the microscopic scale.Experimental manipulation techniques at the microscopic level are demanded to enable in-depth studies regarding the regulation of chemical reactions,material structures,and properties.The development and application of microscopic research methods have become an emerging trend in physical chemistry.Techniques featuring the use of optical,magnetic,and acoustic tweezers have been developed to manipulate objects at the microscopic scale.Optical tweezers use momentum transfer between light and objects to manipulate objects and can stably trap and manipulate mesoscopic particles,even single molecules,by exerting pico-newton force.With advantages including non-invasiveness,nondamaging,and ultra-high sensitivity,optical tweezers are ideal for studying individual molecules,molecular aggregates,condensed matter,chemical bonds,and intermolecular interactions.This technique has the potential to revolutionize the fields of chemistry,physics,information technology,and life sciences.Arthur Ashkin was awarded the 2018 Nobel Prize in Physics for his contribution to the development of this technique.The trapping force of the conventional optical tweezers technique originates from the light intensity gradient.Because of the diffraction limit of light,the trapping and manipulation of micro-nano objects<100 nm in size with traditional optical tweezers is difficult.However,simply increasing the optical power used for trapping induces serious thermal effects and photodamage.By developing unique materials and structures coupled with optical tweezers,researchers have broken the diffraction limit of light and achieved sub-nanometer single-molecule trapping.In this review,we summarize the recent advances in the application of various optical tweezers techniques in physical chemistry and demonstrate the technical principles of fiber,photonic crystal,and plasmonic optical tweezers,respectively.We focus on the development and application of plasmonic optical tweezers and single-molecule plasmonic optical trapping based on tunable nanogaps.Generally,optical tweezers can realize the trapping and manipulation of molecular-scale particles via two main technical routes.The first route is improving the laser focusing ability through unique optical path design and optical component fabrication.The second involves enhancing the trapping field through ingenious auxiliary structure design.Finally,we present the promising future developments and applications of optical tweezers technology.
作者
霍春安
邱圣杰
梁青满
耿碧君
雷志超
王干
邹玉玲
田中群
杨扬
Chun-An Huo;Sheng-Jie Qiu;Qing-Man Liang;Bi-Jun Geng;Zhi-Chao Lei;Gan Wang;Yu-Ling Zou;Zhong-Qun Tian;Yang Yang(Pen-Tung Sah Institute of Micro-Nano Science and Technology,State Key Laboratory of Physical Chemistry of Solid Surfaces,Xiamen University,Xiamen 361005,Fujian Province,China.)
出处
《物理化学学报》
SCIE
CAS
CSCD
北大核心
2024年第1期3-19,共17页
Acta Physico-Chimica Sinica
基金
国家自然科学基金(T2222002,21973079,21991130)
福建省自然科学基金(2021J06008)资助项目。
关键词
光镊
单分子
捕获尺寸
微尺度操控
等离激元
固液界面
Optical tweezers
Single-molecule
Trapping volume
Microscale manipulation
Plasmon
Solid-liquid interface
