摘要
目的探究肺炎支原体感染儿童血清肺炎支原体免疫球蛋白(Ig)G、Ig M抗体、C-反应蛋白(CRP)及D-二聚体(D-D)水平及预测预后的临床价值。方法选择2021年3月~2023年3月于本院接受治疗的肺炎支原体感染儿童220例,作为观察组,并选取同时期体检健康儿童30例,作为对照组。比较两组血清Ig G、Ig M抗体、CRP及D-D水平,并采用单因素及多因素分析其与儿童肺炎支原体感染预后之间的关系,绘制受试者工作特征曲线(ROC)分析血清Ig G、Ig M抗体、CRP及D-D水平预测患儿预后的临床价值。结果观察组Ig G抗体、Ig M抗体、CRP和D-D含量均高于对照组(P<0.05)。观察组中治疗预后不佳56例(25.45%),单因素分析发现,预后不佳与预后良好组住院时间、是否集体生活、有无抗菌药物应用、Ig G抗体、Ig M抗体、CRP及D-D含量等指标的差异均有统计学意义(P<0.05);Logistic多因素分析显示Ig G抗体、Ig M抗体、CRP和D-D均为肺炎支原体感染儿童预后的独立影响因素(P<0.05)。ROC曲线分析显示Ig G、Ig M抗体、CRP及D-D水平预测肺炎支原体感染儿童预后不佳的AUC分别为0.644、0.849、0.752和0.861(P<0.05),敏感度分别为0.625、0.857、0.768和0.768,特异度分别是0.628、0.811、0.701和0.927,均有一定预测价值。结论血清肺炎支原体Ig G、Ig M抗体、CRP及D-D水平与儿童肺炎支原体感染及预后密切相关,其中CRP预测患儿预后效果最好,建议临床上予以密切监测。
Objective To investigate serum levels of Mycoplasma pneumoniae immunoglobulin(Ig)G antibody,IgM antibody,C-reactive protein(CRP)and D-dimer(D-D)in children with Mycoplasma pneumoniae infection and their prognostic value.Methods A total of 220 children with Mycoplasma pneumoniae infection who were treated in the hospital from March 2021 to March 2023 were selected as the observation group.At the same time,30 healthy children who received health check-ups in the hospital during the same period were selected as the control group.Serum levels of IgG antibody,IgM antibody,CRP and D-D in the two groups were compared.The prognostic value of serum IgG antibody,IgM antibody,CRP and D-D was analyzed using the receiver operating characteristic curve(ROC).Results The levels of IgG antibody,IgM antibody,CRP and D-D in the observation group were higher than those in the control group(P<0.05).In the observation group,there were 56(25.45%)cases of poor prognosis after treatment.Univariate analysis found that length of hospital stay,group living,use of antibiotics,IgG antibody,IgM antibody,CRP and D-D levels were prognostic factors(P<0.05).Multivariate logistic analysis found that IgG antibody,IgM antibody,CRP and D-D were independent prognostic factors in children with Mycoplasma pneumoniae infection(P<0.05).ROC analysis results showed that the AUC values of IgG antibody,IgM antibody,CRP and D-D for predicting poor prognosis of children with Mycoplasma pneumoniae infection were 0.644,0.849,0.752 and 0.861(P<0.05).The sensitivity was 0.625,0.857,0.768 and 0.768.The specificity was 0.628,0.811,0.701 and 0.927.Conclusion Serum levels of Mycoplasma pneumoniae IgG antibody,IgM antibody,CRP and D-D are closely related to the prognosis of children with Mycoplasma pneumoniae infection.Among above indexes,CRP is the best for predicting the prognosis.Therefore,it is recommended to closely monitor it in clinical practice.
作者
王颖
刘煜
王娅
WANG Ying;LIU Yu;WANG Ya(Laboratory of pathology,The Chinese People's Liberation Army Unit 95829 Hospital,Wuhan 430012,Hubei Province,China;Pharmacy Department,The Chinese People's Liberation Army Unit 95829 Hospital,Wuhan 430012,Hubei Province,China)
出处
《罕少疾病杂志》
2024年第3期40-42,共3页
Journal of Rare and Uncommon Diseases
