摘要
阿尔茨海默病(Alzheimer’s disease,AD)是以认知障碍为特征的中枢神经系统退行性疾病,出现临床症状前有长达约20年的临床前期,是AD干预的最佳时间窗,因此早期诊断对延缓病情和改善预后至关重要。静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)具有无创性和高时空分辨率等优势,是研究AD脑功能活动异常最广泛使用的神经成像技术之一,为寻找早期AD非侵入性标记物提供了可能。本文就rs-fMRI技术在AD早期诊断的应用价值进行综述,以期找到早期监测AD的非侵入性影像学标记物。
Alzheimer's disease(AD)is a degenerative disease of the central nervous system characterized by cognitive impairment.There is a preclinical period of approximately 20 years before the onset of clinical symptoms,making it the optional time window for disease intervention.Therefore,the early diagnosis of AD is essential for disease delay and prognosis improvement.Resting-state functional magnetic resonance imaging(rs-fMRI)has the advantages of non-invasive and high spatial-temporal resolution.It is one of the most widely used neuroimaging techniques to study brain functional activity abnormalities in AD,which provides the possibility to find non-invasive markers of early AD.Based on rs-fMRI techniques,we reviewed the application value in the early diagnosis of AD in this article,in order to find non-invasive imaging markers for early monitoring of AD.
作者
何雨洁
闫少珍
卢洁
HE Yujie;YAN Shaozhen;LU Jie(Department of Radiology and Nuclear Medicine,Xuanwu Hospital Capital Medical University,Beijing Key Laboratory of MRI and Brain Informatics,Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing 100053,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第1期173-178,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
“十四五”国家重点研发计划项目(编号:2022YFC2406900)
国家自然科学基金项目(编号:82102010)
北京市科技计划项目(编号:Z201100005520018)。
关键词
阿尔茨海默病
轻度认知障碍
主观认知下降
静息态功能磁共振成像
磁共振成像
早期诊断
Alzheimer's disease
mild cognitive impairment
subjective cognitive decline
resting-state functional magnetic resonance imaging
magnetic resonance imaging
early diagnosis
