摘要
目的分析非霍奇金淋巴瘤(NHL)患者个案管理期间化疗耐受性的影响因素及其与自我接纳水平的关系。方法选择2020年7月—2022年7月赣州市人民医院收治的135例NHL患者进行前瞻性研究,所有患者均实施个案管理干预+利妥昔单抗+环磷酰胺+多柔比星+长春新碱+泼尼松(R-CHOP)方案化疗,21 d为1个治疗周期,共治疗4个周期。并在护理及化疗方案实施前评估自我接纳水平[自我接纳问卷(SAQ)]。统计4个周期内NHL患者化疗耐受情况并分组为耐受组与不耐受组,分析NHL化疗患者自我接纳对化疗耐受性的影响。结果135例NHL患者中化疗不耐受55例,占比40.74%,化疗耐受性良好80例,占比59.26%;不耐受组SAQ评分均低于耐受组,空腹血糖、白细胞计数、血小板计数高于耐受组,差异有统计学意义(P<0.05);经点二列相关检验,NHL化疗患者自我接纳水平与化疗耐受性呈正相关(r=0.584,P<0.001);建立多因素Logistic回归模型,结果显示,SAQ评分、空腹血糖水平及白细胞计数是NHL患者化疗不耐受的影响因素(P<0.05),其中SAQ评分越高,NHL化疗患者出现化疗不耐受的危险性越低;空腹血糖水平及白细胞计数水平越高,NHL化疗患者出现化疗不耐受的危险性越高。结论NHL患者个案管理期间化疗耐受性受自我接纳水平、空腹血糖及白细胞计数等因素影响,自我接纳水平与NHL患者个案管理期间化疗耐受性有关,患者的自我接纳水平越高,患者化疗耐受性越好。
Objective To analyze the infl uencing factors of chemotherapy tolerance during case management of non-Hodgkin's lymphoma(NHL)patients and their relationship with self-acceptance level was as the study subject.Methods We selected 135 NHL patients admitted to Ganzhou People's Hospital from July 2020 to July 2022 for a prospective study.All patients received case management intervention+rituximab+cyclophosphamide+doxorubicin.+vincristine+prednisone(R-CHOP)regimen chemotherapy,with 21 days as one treatment cycle,and a total of 4 cycles of treatment.And we assessed self-acceptance levels[self acceptance questionnaire(SAQ)]before implementation of care and chemotherapy regimens.The chemotherapy tolerance of NHL patients within 4 cycles was counted and divided into tolerance and intolerance groups,and the impact of self-acceptance of NHL chemotherapy patients on chemotherapy tolerance was analyzed.Results Among the 135 NHL patients,55 cases were intolerant to chemotherapy,accounting for 40.74%,and 80 cases were well tolerated by chemotherapy,accounting for 59.26%;the SAQ scores of the intolerant group were lower than those of the tolerant group,and the fasting blood glucose,white blood cell count,and platelet count were higher than those of the tolerant group,the differences were statistically signifi cant(P<0.05);through point biserial correlation test,the self-acceptance level of NHL chemotherapy patients was positively correlated with chemotherapy tolerance(r=0.584,P<0.001);a multifactor Logistic regression model was established,and the results showed that SAQ score,fasting blood glucose level and white blood cell count were infl uencing factors of chemotherapy intolerance in NHL patients(P<0.05).The higher the SAQ score,the lower the risk of chemotherapy intolerance in NHL chemotherapy patients;the higher the fasting blood glucose level and white blood cell count level,the higher the risk of chemotherapy intolerance in NHL chemotherapy patients.Conclusion Chemotherapy tolerance during case management of NHL patients is aff ected by factors such as self-acceptance level,fasting blood glucose and white blood cell count.The level of self-acceptance is related to the tolerance of chemotherapy during case management of NHL patients.The higher the patient's self-acceptance level,the better the tolerance of chemotherapy.
作者
廖林英
曹雯燕
曹倩莹
韩小玉
朱雪梅
LIAO Linying;CAO Wenyan;CAO Qianying;HAN Xiaoyu;ZHU Xuemei(Ganzhou People's Hospital,Ganzhou 341000,China)
出处
《护理实践与研究》
2024年第3期414-420,共7页
Nursing Practice and Research
