摘要
目的:分析滋阴疏肝清瘀法联合达格列净治疗女性2型糖尿病(T2DM)性功能障碍的疗效。方法:选择2023年1~4月就诊于医院的60例女性T2DM性功能障碍患者,按随机对照原则分为对照组与研究组,各30例。对照组接受达格列净+二甲双胍治疗,研究组接受达格列净联合二甲双胍及中药滋阴疏肝清瘀法治疗,两组均治疗3个月。对比两组血糖指标、性激素水平、肝肾功能、性功能障碍情况及不良反应情况。结果:治疗3个月后研究组女性性功能指数(FSFI)评分比对照组高,糖化血红蛋白(HbA1c)、空腹血糖(FPG)水平比对照组低(P<0.05);治疗3个月后,研究组血清卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)水平与对照组相比,差异无统计学意义(P>0.05),但相比本组治疗前,血清E2水平升高,LH、FSH水平下降(P<0.05);研究组血清丙氨酸转氨酶(ALT)、血清天冬氨酸转氨酶(AST)、血肌酐(SCr)、尿素氮(BUN)水平、尿路感染发生率与对照组相比,差异无统计学意义(P<0.05)。结论:滋阴疏肝清瘀法联合达格列净治疗女性T2DM性功能障碍,能有效降低患者血糖水平,减轻性功能障碍程度,且不会影响肝肾功能及增加药物不良反应,可保证用药安全性。
Objective:To analyze the curative effect of nourishing yin,soothing liver and removing blood stasis combined with dapagliflozin in treating female sexual dysfunction in type 2 diabetes mellitus(T2DM).Method:Sixty female T2DM patients with sexual dysfunction from January to April,2023 were randomly divided into control group and study group,with 30 cases in each group.The control group received treatment with dapagliflozin and metformin,while the study group received treatment with dapagliflozin combined with metformin and traditional Chinese medicine nourishing yin,soothing liver,and removing blood stasis,for a total of 3 months.The differences of blood glucose indicators,sex hormone levels,liver and kidney function,sexual dysfunction and adverse reactions between two groups were compared.Results:After 3 months of treatment,the score of female sexual function index(FSFI)in the study group was higher than that in the control group,while glycosylated hemoglobin(HbA1c)and fasting blood glucose(FPG)were lower than those in the control group(P<0.05).After 3 months of treatment,there was no statistically significant difference in serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)between the study group and the control group(P>0.05).However,compared with before treatment,serum E2 increased while LH and FSH decreased(P<0.05).There was no statistically significant difference in the levels of serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),serum creatinine(SCr),urea nitrogen(BUN),and incidence of urinary tract infections between the two group(P<0.05).Conclusion:The method of nourishing yin,soothing liver and removing blood stasis combined with dapagliflozin caneffectively reduce blood glucose level of female T2DM patients and reduce the degree of sexual dysfunction,will not affect iver and kidney function or increase adverse reactions,ensuring medication safety.
作者
丁凯
朱雯丽
贾静静
朱艳
DING Kai;ZHU Wen-li;JIA Jing-jing;ZHU Yan(Xuzhou Hospital of Traditional Chinese Medicine,Xuzhou,Jiangsu221000)
出处
《实用中西医结合临床》
2024年第3期7-11,共5页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金
江苏省徐州市卫生健康委员会科技青年项目(编号:XWKYHT20220129)。
关键词
2型糖尿病
滋阴疏肝清瘀法
达格列净
性功能障碍
性激素
Type 2 diabetes
Nourishing Yin,soothing liver,and removing blood stasis method
Dapagliflozin
Sexual dysfunction
Sex hormone
