摘要
目的 分析云南省传染病医院抗病毒门诊595例HIV/HCV共感染者的HCV基因型及临床特征,为HIV/HCV防治提供参考。方法 选取2022年1月~2023年7月在云南省传染病医院抗病毒门诊就诊的HIV/AIDS患者为研究对象,采用横断面研究,收集患者基本信息,检测HCV抗体、HCV RNA、HCV基因型、生化指标,并进行分析。结果 筛查5709例HIV/AIDS患者,HCV抗体阳性率10.42%(595/5709),HCV RNA检测率86.72%(516/595),HCV RNA阳性率47.09%(243/516)。95.47%HCV RNA阳性完成HCV基因检测,其中各型占比为:1b型(14.66%)、2a型(0.86%)、3a型(27.59%)、3b型(40.95%)、6型(14.66%)、未分型(1.29%)。HCV RNA阳性者中FIB-4评分> 3.25为37.86%。不同感染途径的HIV/HCV共感染者丙肝基因分型差异有统计学意义(P <0.05),基因分型为3a、3b的FIB-4指数均高于其他基因型,两两比较差异均有统计学意义(均P <0.05)。结论 HIV/AIDS患者中HCV抗体、HCV RNA阳性率较高,HCV基因型以3b型、3a型为主要流行株,发生进展性肝脏纤维化占比较高。在HIV/AIDS患者中进行HCV感染的筛查对早期诊断及早期治疗丙型肝炎具有重要意义。
Objective To analyze the HCV genotypes and clinical characteristics of 595 cases of HIV/HCV co-infected patients in antiretroviral outpatient clinic of Yunnan Provincial Infectious Disease Hospital,and to provide reference for the prevention and treatment of HIV/HCV.Methods The HIV/AIDS patients who were treated in the antiviral clinic of Yunnan Infectious Diseases Hospital from January 2022 to July 2023 were selected for the study,and a cross-sectional survey was used to collect basic information,HCV antibodies,HCV RNA,HCV genotype and biochemistry.Results Screening 5709 patients with HIV/AIDS,HCV antibody positive rate of 10.42%(595/5709);HCV RNA detection rate of 86.72%(516/595),HCV RNA positive rate of 47.09%(243/516).95.47%of HCV RNA positive completed HCV genetic testing,of which the proportion of each type is:type 1b(14.66%),type 2a(0.86%),type 3a(27.59%),type 3b(40.95%),type 6(14.66%),and unidentified type(1.29%).The rate of FIB-4 score>3.25 was 37.86%among HCV RNA-positive patients.There was significant difference in hepatitis C genotyping among HIV/HCV co-infected patients with different routes of infection(P<0.05),and the FIB-4 indexes of the genotypes 3a,3b were higher than those of the other genotypes,and the FIB-4 indexes of 3a and 3b genotypes were all statistically significance(all P<0.05).Conclusion HCV antibody and HCV RNA positivity rates are high in HIV-infected populations,and HCV genotypes 3b and 3a are the main prevalent strains,with a high percentage of progressive liver fibrosis occurring.Screening of HCV infection in patients with HIV/AIDS is of great significance for early diagnosis and early treatment of hepatitis C.
作者
李肖
刘仕芳
杨韵秋
宋晓
刘俊仪
亢丽娟
徐艳江
尚灿珠
何全英
李惠琴
Li Xiao;Liu Shifang;Yang Yunqiu;SongXiao;Liu Junyi;Kang Lijuan;Xu Yanjiang;Shang Canzhu;He Quanying;Li Huiqin(School of Public Health,Kunming Medical University,Kunming Yunnan 650500,China;Yunnan Provincial Infectious Disease Hospital,Kunming Yunnan 650301,China;School of Public Health,Dali University,Dali Yunnan 671013,China)
出处
《皮肤病与性病》
2024年第1期1-4,共4页
Dermatology and Venereology
基金
国家自然科学基金项目(81960605)
云南省科技厅重大科技专项计划(202102AA310005)
云南省李太生专家工作站项目(202105AF150023)。
