摘要
目的 探讨焦虑症患者红细胞免疫黏附调节因子表达及其对临床疗效的预测价值。方法选取180例焦虑症患者设为观察组,180名健康志愿者设为对照组。两组受试者均进行红细胞免疫黏附调节因子检测,比较两组检测结果。同时比较不同疗效患者红细胞免疫黏附调节因子水平。绘制受试者工作特征(ROC)曲线分析红细胞免疫黏附调节因子对焦虑症诊断价值及对临床疗效的预测价值。结果 观察组受试者红细胞免疫抑制因子、免疫黏附促因子、循环免疫复合物、β-内啡肽水平及红细胞-免疫复合植物花环率均高于对照组,酵母花环率低于对照组(P<0.01)。ROC曲线分析显示,6种红细胞免疫黏附调节因子诊断焦虑症的曲线下面积(AUC)分别为0.770、0.747、0.698、0.729、0.722、0.863,6项指标联合诊断焦虑症的AUC为0.991,高于单项诊断效能(Z=4.266、4.760、5.742、4.106、4.022、4.464,P<0.05或0.01)。180例患者中,疗效良好144例,疗效较差36例;疗效良好患者5种红细胞免疫黏附调节因子水平均低于疗效较差患者,酵母花环率高于疗效较差患者,差异有统计学意义(P<0.01)。6种红细胞免疫黏附调节因子预测焦虑症治疗无效的AUC分别为0.786、0.845、0.777、0.866、0.745、0.902,6项指标联合预测焦虑症治疗无效的AUC为0.990,高于单项预测效能(Z=2.880、2.286、3.049、2.662、3.049、2.182,P<0.01)。结论 焦虑症患者红细胞免疫黏附调节因子表达异常,且与预后关系密切,检测该指标能为焦虑症诊断和临床疗效评估提供科学依据。
Objective To explore the expression of erythrocyte immunoadhensive regulatory factor(EIARF) and its predictive value for clinical effect of anxiety disorder patients.Methods A total of180 anxiety patients were selected as observation group and 180 healthy volunteers as control group.The EIARFs were detected in both groups and detection results compared.EIARF levels were compared among patients with different effects simultaneously.Receiver operating characteristic(ROC) curve was plotted to analyze the diagnostic value of the EIARF for anxiety and its predictive value for clinical effect.Results The levels of erythrocyte immunosuppressive factor,immune adhesion promoting factor,circulating immune complexes,and β-endorphins as well as erythrocyteimmune complex rosette rate were higher and yeast rosette rate was lower in observation than control group(P<0.01).ROC curve analysis showed that the areas under the curve(AUC) of six EIARFs in diagnosing anxiety were 0.770,0.747,0.698,0.729,0.722 and 0.863,respectively,that of 6 indicator combination in diagnosing anxiety was 0.991 and higher than single diagnostic efficacy(Z=4.266,4.760,5.742,4.106,4.022,and 4.464,P<0.05 or 0.01).Of the 180 patients,144 cases had good effect and 36 poor;the levels of 5 EIARFs were lower and yeast rosette rate was higher in patients with good effect than ones poor,the differences were statistically significant(P<0.01).The AUCs of6 EIARFs predicting treatment failure of anxiety were 0.786,0.845,0.777,0.866,0.745,and 0.902,respectively,that of 6 indicator combination was 0.990 and higher than the single predictive efficacy(Z=2.880,2.286,3.049,2.662,3.049,and 2.182,P<0.01).Conclusion The expressions of EIARFs in anxiety disorder patients are abnormal and closely related to prognosis,the detection of the indicators can provide scientific basis for the diagnosis and clinical efficacy evaluation of anxiety.
作者
王贵贤
王慧颖
陈永新
郭新胜
杨焦峰
Wang Gui xian;Wang Huiying;Chen Yongxin;Guo Xin sheng;Yang Jiaofeng(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan,China)
出处
《临床心身疾病杂志》
CAS
2024年第2期1-6,共6页
Journal of Clinical Psychosomatic Diseases
基金
河南省重点研发与推广专项(科技攻关、软科学研究)项目(编号222102310555)。
