摘要
Objective:Magnetic resonance imaging(MRI)studies have demonstrated anatomical and functional alterations of brain regions in patients with migraine,and the efficacy of acupuncture for migraine could regulate these abnormal alterations.However,its pathogenesis remains ambiguous,and inconsistent results have been reported.The purpose of this study was to explore abnormal structural and functional alterations in patients with migraine using voxel-based morphometry(VBM)analysis and a seed-based functional connectivity(FC)approach and to provide a basis for future research.Methods:The study recruited 34 patients with migraine and 38 healthy controls who underwent structural and resting-state functional magnetic resonance imaging(fMRI).VBM was evaluated across the whole brain,and group differences in the gray matter(GM)were compared.The significantly altered GM volumes considered as the seeding area were further calculated for the FC of the whole brain.The correlation between structural or functional changes of the brain and clinical features was also evaluated.Results:Patients with migraine manifested higher GM volumes in the left occipital lobe than healthy controls.Seed-based analyses demonstrated reduced FC between the left occipital lobe and right inferior frontal gyrus,extending to the anterior cingulate cortex(ACC)and right insula.Decreased FC in the left ACC was positively correlated with visual analog scale(VAS)and self-rating anxiety scale(SAS).
作者
刘国韵
陈懿超
曹子敏
石安琪
许璐凡
李芷君
杨泽秋
闫超群
王军
Guo-yun LIU;Yi-chao CHEN;Zi-min CAO;An-qi SHI;Lu-fan XU;Zhi-jun LI;Ze-qiu YANG;Chao-qun YAN;Jun WANG(Department of Acupuncture and Moxibustion,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,100700,China)
基金
Supported by National Natural Science Foundation of China Youth Fund:82004197
Department of Science and Technology,National Administration of Traditional Chinese Medicine:GZY-KJS-2022-029
The fifth batch of national research and training programs for clinical talents of traditional Chinese medicine,Project for new teachers of Beijing University of Chinese Medicine:2020-JYB-XJSJJ-045。
