摘要
目的:探讨非小细胞肺癌患者接受胸腔镜手术后的并发症及其对预后的影响。方法:本研究随机选择2017年06月至2020年06月在我院进行胸腔镜肺癌切除术治疗的102例非小细胞肺癌患者作为研究对象,收集患者临床及随访资料并进行分析。Logistic回归探讨影响术后并发症或严重并发症的危险因素。以复发为终点进行生存分析,比较不同组别患者之间无复发生存率的差异。结果:在纳入的102例患者中,我们发现,患者年龄(OR=4.009,95%CI:1.209~13.299,P=0.023)、糖尿病(OR=3.515,95%CI:1.045~11.819,P=0.042)、手术时间(OR=1.014,95%CI:1.002~1.026,P=0.020)、术中出血量(OR=1.016,95%CI:1.008~1.025,P<0.001)均为术后并发症的影响因素。同时,手术时间(OR=1.123,95%CI:1.008~1.252,P=0.036)为术后严重并发症的影响因素。并发症组的术后住院时间较无并发症组明显延长(P<0.001)。无并发症患者的无复发生存率显著高于有并发症患者(HR=1.43,95%CI:1.03~1.99,P=0.033),无严重并发症患者的无复发生存率明显高于严重并发症患者(HR=1.61,95%CI:1.15~2.24,P=0.005)。结论:对于接受胸腔镜手术治疗的非小细胞肺癌患者,年龄、糖尿病、手术时间、术中出血量是术后并发症的独立影响因素,且术后并发症可显著降低患者的无复发生存期。
Objective:To investigate the postoperative complications of non-small cell lung cancer patients underwent video-assisted thoracoscopic surgery and its impact on the prognosis of patients.Methods:A total of 102 patients with non-small cell lung cancer who underwent video-assisted thoracoscopic surgery in our hospital from June 2017 to June 2020 were randomly selected as the study subjects.The clinical and follow-up data were collected and analyzed.Logistic regression analysis explored the risk factors affecting postoperative complications or severe complications.Survival analysis was performed with relapse as the endpoint and the differences in relapse free survival among different groups of patients were compared.Results:Among the 102 patients included,we found that the patient's age(OR=4.009,95%CI:1.209~13.299,P=0.023),diabetes(OR=3.515,95%CI:1.045~11.819,P=0.042),operation time(OR=1.014,95%CI:1.002~1.026,P=0.020),and intraoperative blood loss(OR=1.016,95%CI:1.008~1.025,P<0.001) were influencing factors for postoperative complications.At the same time,operation time(OR=1.123,95%CI:1.008~1.252,P=0.036) were the influencing factors for severe postoperative complications.The postoperative hospital stay in the complication group was significantly longer than that in the non-complication group(P<0.001).The relapse-free survival rate of patients without complications were significantly higher than that of patients with complications(HR=1.43,95%CI:1.03~1.99,P=0.033).The relapse-free survival rate of patients without severe complications were significantly higher than that of patients with severe complications(HR=1.61,95%CI:1.15~2.24,P=0.005).Conclusion:For patients with non-small cell lung cancer underwent video-assisted thoracoscopic surgery,age,diabetes,operation time,and intraoperative blood loss were independent influencing factors of postoperative complications,and postoperative complications can significantly reduce the relapse-free survival of patients.
作者
苏鹏
田子强
徐延昭
吕会来
李振华
温士旺
SU Peng;TIAN Ziqiang;XU Yanzhao;LYU Huilai;LI Zhenhua;WEN Shiwang(The Fifth Department of Thoracic Surgery,Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050011,China)
出处
《现代肿瘤医学》
CAS
2024年第5期857-862,共6页
Journal of Modern Oncology
基金
河北省医学科学研究课题计划(编号:20221223)。
关键词
非小细胞肺癌
胸腔镜
并发症
糖尿病
预后
non-small cell lung cancer
thoracoscopy
complications
diabetes
prognosis
