摘要
免疫疗法的出现改变了现有的晚期肿瘤治疗模式,为患者带来了希望。然而,许多肿瘤已经显示出对检查点抑制等免疫治疗的显著抵抗机制,导致部分患者的应答率始终不高,甚至超进展。通过对新兴免疫代谢领域的研究发现,靶向代谢途径重塑肿瘤微环境有望重振抗肿瘤免疫反应,并可能与现有免疫疗法产生协同效应。本文着重探讨了代谢检查点调节T细胞代谢在肿瘤免疫治疗中产生的一系列影响,旨在为肿瘤免疫治疗提供新的思路。
The emergence of immune checkpoint inhibitors has redefined the treatment of advanced tumors and brought hope to patients.However,many tumors have shown significant mechanisms of resistance to checkpoint suppression and other immunotherapies,resulting in consistently low response rates or even superprogression in some patients.Targeting metabolic pathways to reshape the tumor microenvironment is expected to revitalize anti-tumor immune responses and may have synergistic effects with existing immunotherapies,according to the emerging field of immunometabolism.This article focuses on a series of effects of regulating T cell metabolism through metabolic checkpoint in tumor immunotherapy,aiming to provide new ideas for tumor immunotherapy.
作者
杨力
梅婷婷
马宇亮
陈晶
闫珺
隋博文
YANG Li;MEI Tingting;MA Yuliang;CHEN Jing;YAN Jun;SUI Bowen(Heilongjiang University of Chinese Medicine,Heilongjiang Harbin 150000,China;Heilongjiang University of Technology,Heilongjiang Jixi 158100,China;The First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Heilongjiang Harbin 150000,China)
出处
《现代肿瘤医学》
CAS
2024年第5期967-972,共6页
Journal of Modern Oncology
基金
黑龙江省应用技术研究与开发计划项目(编号:GA19C109)
黑龙江省博士后基金资助项目(编号:LBH-Z18251)
黑龙江省中医药管理局科研项目(编号:ZHY2022-155)
黑龙江省哈尔滨市技术创新人才研究专项资金(编号:2017RAQXJ186)。
关键词
代谢检查点
免疫检查点
肿瘤微环境
免疫疗法
metabolic checkpoint
immune checkpoint
tumor microenvironment
immunotherapy
