摘要
目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予抗血小板聚集等治疗措施,观察组在此基础上联合扶阳急救汤加减治疗。两组均持续治疗2周。比较两组患者的临床疗效、中医证候评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评分、凝血功能及3个月后改良RANKIN量表(Modified Rankin Scale, mRS)评分。结果 治疗后,观察组总有效率较高(P<0.05)。治疗1周、2周后,两组中医证候主证、次证、总积分和NIHSS评分逐渐明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗2周后,对照组凝血酶原时间(Prothrombin time, PT)、活化的部分凝血活酶时间(Activated partial thromboplastin time, APTT)、纤维蛋白原(Fibrinogen, FIB)、凝血酶时间(Thrombin time, TT)水平较治疗前差异无统计学意义(P>0.05),观察组PT、TT水平较治疗前差异无统计学意义(P>0.05),APTT及FIB水平则明显降低(P<0.05),且显著低于对照组(P<0.05)。治疗后3个月,观察组mRS评分显著低于对照组(P<0.05)。结论 扶阳急救汤加减治疗可以更好地促进痰瘀阻络证型急性脑梗死患者神经功能及中医证候的恢复,提高患者近期疗效及长期生活质量,且并未影响凝血功能,有较好的安全性,值得临床应用。
Objective To explore the curative effect of Modified Fuyang Jiuji Decoction(扶阳急救汤)on patients with acute cerebral infarction and its influence on patients'TCM syndrome scores,stroke scale scores and coagulation function.Methods One hundred and twenty patients with acute cerebral infarction admitted to Taihe Hospital of Traditional Chinese Medicine,Anhui University of Traditional Chinese Medicine from June 2020 to June 2022 were divided equally into observation group and control group.The control group was given antiplatelet aggregation and other therapeutic measures,while the observation group was treated with the combination of Modified Fuyang Jiuji Decoction on this basis.Both groups were treated for 2 weeks.The clinical efficacy,TCM symptom scores,National Institute of Health stroke scale(NIHSS)score,coagulation function and Modified Rankin Scale(mRS)score after 3 months were compared between the two groups.Results After treatment,the overall effective rate was higher in the observation group(P<0.05).After 1 and 2 weeks of treatment,the main symptoms,secondary symptoms,total score and NIHSS score of TCM symptom scores gradually decreased significantly in two groups(P<0.05),and those of the observation group were significantly lower than those of the control group(P<0.05).After 2 weeks of treatment,the levels of prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)and fibrinogen(FIB)in the control group were not statistically significant compared with those before treatment(P>0.05),while the levels of PT and TT in the observation group were not statistically significant compared with those before treatment(P>0.05),and the levels of APTT and FIB were significantly lower(P<0.05)and significantly lower(P<0.05)compared with those in the control group.At 3 months after treatment,the mRS score in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Fuy-ang Jiuji Decoction can better promote the recovery of neurological function and TCM syndromes of patients with acute cerebral infarction of phlegm-stagnation and collateral obstruction type and improve the short-term efficacy and long-term quality of life of patients,without affecting coagulation function.It has a good safety,and is worthy of clinical application.
作者
付耀武
刘路遥
刘祖标
丁昊鹏
王邱
王靓
FU Yaowu;LIU Luyao;LIU Zubiao;DING Haopeng;WANG Qiu;WANG Liang(Taihe Hospital of Traditional Chinese Medicine,Anhui University of Traditional Chinese Medicine,Fuyang 236600,Anhui,China;Clinical College of Integrated Traditional and Western Medicine,Anhui University of Traditional Chinese Medicine,Hefei 230031,Anhui,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第3期70-73,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局中医药行业科研项目(201909007836)。
关键词
扶阳急救汤
急性脑梗死
中医证候评分
卒中量表评分
凝血功能
Fuyang Jiuji Decoction(扶阳急救汤)
acute cerebral infarction
TCM syndrome score
stroke scale score
coagulation function
