摘要
目的探讨双歧杆菌三联活菌在混合痔选择性痔上黏膜吻合术(TST)术后患者中的应用价值,为临床预防术后便秘提供参考。方法选取2021年8月至2023年2月我院收治的100例混合痔TST术后患者为研究对象,并分为对照组(n=46,接受莫沙必利治疗)和研究组(n=54,接受莫沙必利联合双歧杆菌三联活菌治疗)。持续治疗2周后,比较两组患者术后便秘发生情况、术后恢复情况(排气时间、排便时间、住院时间)、排便困难程度、粪便性状、肠道菌群数量、血清P物质(SP)、血管活性肠肽(VIP)水平。结果研究组患者便秘发生率低于对照组(χ^(2)=4.617,P=0.032)。研究组患者首次排气时间、排便时间及住院时间均短于对照组(t=15.103、13.358、8.463,均P<0.001)。治疗2周后,研究组患者排便困难程度及粪便性状评分均低于对照组(t=5.221、4.001,均P<0.001)。研究组患者肠道乳杆菌、双歧杆菌数量高于对照组,肠杆菌、球杆菌、酵母菌数量均低于对照组(t=4.646、3.688、2.454、4.818、8.681,均P<0.001)。研究组患者血清SP水平高于对照组,VIP水平低于对照组(t=3.328、8.999,均P<0.001)。结论双歧杆菌三联活菌可预防混合痔TST术后患者便秘的发生,同时优化患者肠道菌群及脑肠肽类激素分泌。
Objective To explore the application value of Bifidobacterium Triple Viable Bacteria(BTVB)in patients with mixed hemorrhoids after selective mucosal anastomosis(TST),so as to guide clinical prevention of postoperative constipation.Methods A total of 100 patients with mixed hemorrhoids after TST in our hospital from August,2021 to February,2023 were selected as the subjects,and were divided into control group(n=46,receiving Mosapride treatment)and research group(n=54,receiving Mosapride combined with BTVB treatment).After two weeks of continuous treatment,the incidence of postoperative constipation,postoperative recovery(time to flatulence,time to defecation and hospitalization days),difficulty in defecation,fecal characteristics,counts of intestinal flora,serum substance P(SP)and vasoactive intestinal peptide(VIP)levels were statistically compared between the two groups.Results The incidence of constipation in the research group was lower than that in the control group(χ^(2)=4.617,P=0.032).The time to first flatulence,time to defecation and hospitalization days in the research group were shorter than those in the control group respectively(t=15.103,13.358,8.463,all P<0.001).After two weeks of treatment,the difficulty of defecation and the score of fecal characteristics in the research group were lower than those in the control group(t=5.221,4.001,all P<0.001).The counts of Lactobacillus and Bifidobacterium in the research group were higher,while those of Enterobacter,Coccidium and Yeast were lower than in the control group respectively(t=4.646,3.688,2.454,4.818,8.681,all P<0.001).The serum SP level in the research group was higher,and the VIP level was lower than that in the control group respectively(t=3.328,8.999,all P<0.001).Conclusion Bifidobacterium Triple Viable Bacteria can prevent constipation in patients with mixed hemorrhoids after TST,and optimize the intestinal flora and the secretion of brain and intestinal peptide hormones.
作者
史广麟
奚晓燕
王文婷
SHI Guanglin;XI Xiaoyan;WANG Wenting(Anorectal Department of Zhangjiakou Fifth Hospital,Zhangjiakou,Hebei 075000,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
北大核心
2024年第1期51-55,共5页
Chinese Journal of Microecology
基金
张家口市重点研发计划项目(2121076D)。
关键词
混合痔
双歧杆菌三联活菌
选择性痔上黏膜吻合术
便秘
肠道菌群
Mixed hemorrhoids
Bifidobacterium Triple Viable Bacteria
Selective hemorrhoid mucosal anastomosis
Constipation
Intestinal flora
