摘要
目的 探究星蒌通络饮联合氯吡格雷对老年急性缺血性脑卒中患者认知功能、脑血循环及Netrin-1水平的影响。方法 选取2022年1月—2023年5月邯郸市中心医院收治的80例老年急性缺血性脑卒中患者作为研究对象,按照随机数字表法将其分为观察组(40例)和对照组(40例)。对照组接受氯吡格雷治疗,观察组给予星蒌通络饮联合氯吡格雷治疗,比较两组的临床疗效、脑血循环指标[血流阻力指数(RI)、平均血流速度(Vm)和血管搏动指数(PI)]、血清学指标[Netrin-1和基质金属蛋白酶(MMP)-9]、神经功能[美国国立卫生研究院脑卒中量表(NIHSS)评分]和认知功能[蒙特利尔认知评估量表(MoCA)评分]。结果 观察组的临床总有效率高于对照组(P<0.05);治疗后两组RI和PI均下降,Vm上升,且观察组的RI、PI低于对照组,Vm高于对照组,差异均有统计学意义(P<0.05);治疗后两组Netrin-1均上升,MMP-9均下降,且观察组Netrin-1高于对照组、MMP-9低于对照组,差异均有统计学意义(P<0.05);治疗后两组NIHSS评分均下降,MoCA评分均上升,且观察组的NIHSS评分低于对照组,MoCA评分高于对照组,差异均有统计学意义(P<0.05)。结论 星蒌通络饮联合氯吡格雷能够有效改善老年急性缺血性脑卒中患者的脑血循环和血清Netrin-1水平,提高认知功能。
Objective To investigate the impacts of Xinglou Tongluo drink combined with clopidogrel on cognitive function,cerebral blood circulation,and serum Netrin-1 level in elderly patients with acute ischemic stroke.Methods A total of 80 elderly patients with acute ischemic stroke admitted to Handan Central Hospital from January 2022 to May 2023 were selected as the study subjects.They were randomly divided into an observation group(40 cases)and a control group(40 cases)using a random number table method.The control group received treatment with clopidogrel,while the observation group received treatment with Xinglou Tongluo Yin combined with clopidogrel.The clinical efficacy,cerebral blood circulation indicators[blood flow resistance index(RI),mean blood flow velocity(Vm),and vascular pulsatility index(PI)],serum indicators[Netrin-1 and matrix metalloproteinase-9]and Neurological function[National Institutes of Health Stroke Scale(NIHSS)score]and cognitive function[Montreal Cognitive Assessment Scale(MoCA)score]were compared between the two groups.Results The overall response rate in the observation group was higher than that in the control group(P<0.05);after treatment,RI and PI decreased and Vm increased in both groups,and RI and PI in the observation group were lower than those in the control group,Vm was higher than that in the control group,and the differences were statistically significant(P<0.05);after treatment,Netrin-1 increased and MMP-9 decreased in both groups,and Netrin-1 was higher and MMP-9 was lower in the observation group than in the control group,and the differences were statistically significant(P<0.05);after treatment,NIHSS score decreased and MoCA score increased in both groups,and the NIHSS score in the observation group was lower than that in the control group,MoCA score was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Xinglou Tongluo drink combined with clopidogrel can effectively improve cognitive function and serum Netrin-1 level in elderly patients with acute ischemic stroke,and improve cerebral blood circulation.
作者
胡芳
吕学海
徐艳芬
马艳
赵聪慧
柴佳
刘运平
程晓娜
郝棚娜
Hu Fang;Lv Xuehai;Xu Yanfen;Ma Yan;Zhao Conghui;Chai Jia;Liu Yunping;Cheng Xiaona;Hao Pengna(Handan Central Hospital,Handan 056000;Handan First Hospital,Handan 056002)
出处
《国际老年医学杂志》
2024年第2期157-161,共5页
International Journal of Geriatrics
基金
邯郸市科学技术研究与发展计划项目(22422083027ZC)。
