摘要
为考察灵芝孢子糖肽对荷瘤小鼠的特异性免疫调节作用,建立S180荷瘤小鼠模型,随机设4个处理组(空白组,模型组,阳性药云芝胞内糖肽胶囊组,阳性药环磷酰胺组),灵芝孢子糖肽设低、中、高(130 mg∕kg、260 mg∕kg、520 mg∕kg)三个剂量组。通过对小鼠体重、瘤重、主要脏器的质量、白细胞计数及血清溶血素试验来研究灵芝孢子糖肽对小鼠体内特异性免疫的影响。结果表明:灵芝孢子糖肽对小鼠无明显毒副反应,可以升高小鼠的血清半数溶血值,提高小鼠体内特异性免疫作用,升高白细胞值。灵芝孢子糖肽可以显著降低瘤重。上述结果表明,灵芝孢子糖肽具有一定的抗肿瘤活性,能增强荷瘤小鼠的特异性免疫作用,而无明显毒副作用。
To study the specific immunoregulatory effect of Ganoderma lucidum spore glycopeptide on tumor-bearing mice.The S180 tumor-bearing mouse model was established and randomly divided into blank group,model group,positive drug Yunzhi intracellular glycopeptide group,positive drug cyclophosphamide group,and G.lucidum spore glycopeptide was set as low,medium and high(130 mg∕kg,260 mg∕kg,520 mg∕kg)in three dose groups.The effects of G.lucidum spore glycopeptide on specific immunity in mice were studied by the experiments of mouse body weight,tumor weight,main organ weight,white blood cell count and serum hemolysin.The results showed that G.lucidum spore glycopeptide had no unexpected adverse events occurred on mice,could increase the serum half hemolysis value of mice,improve the specific immune function in mice,and increase the white blood cell value.G.lucidum spore glycopeptide could significantly reduce tumor weight.The above results showed that G.lucidum spore glycopeptide had a certain anti-tumor activity and could enhance the specific immune function of tumor-bearing mice without unexpected adverse events occurred.
作者
胡浪
王颖
周亚杰
钱一帆
郭原
冯鹏
HU Lang;WANG Ying;ZHOU Yajie;QIAN Yifan;GUO Yuan;FENG Peng(Nanjing Zhongke Pharmaceutical Co.,Ltd.,Nanjing 210008,China)
出处
《上海农业学报》
2024年第1期82-87,共6页
Acta Agriculturae Shanghai
关键词
灵芝孢子糖肽
特异性免疫
S180荷瘤小鼠
血清溶血素试验
Ganoderma lucidum spore glycopeptide
Specific immunity
S180 tumor-bearing mice
Serum hemolysin test
