摘要
目的评估全方位视神经管减压治疗无光感外伤性视神经损伤(TON)的疗效。方法选取2015年1月-2021年12月上海交通大学医学院附属第九人民医院神经外科收治的67例无光感TON患者的临床资料进行回顾性分析,其中观察组37例接受全程全方位视神经管减压手术治疗,对照组30例接受非全方位视神经管减压手术治疗。两组术前均接受大剂量糖皮质激素冲击治疗及甲钴胺口服治疗。检查并记录两组患者入院与治疗后的视力变化及并发症发生情况。比较两组治疗后的有效率、脱盲率和并发症发生情况。结果观察组与对照组的年龄、性别、受伤至手术时间、术前格拉斯哥昏迷评分(GCS)分值、手术用时、术中出血量等比较差异均无统计学意义(P>0.05)。治疗后,观察组有效率54.1%、脱盲率35.1%,对照组有效率46.7%、脱盲率33.3%;两组有效率和脱盲率比较差异均无统计学意义(P>0.05)。两组术后均未出现脑脊液漏、癫痫、颅内感染等严重并发症。观察组中,视神经管骨折者治疗后有效率明显低于无视神经管骨折者(P<0.05);受伤至手术时间≤7 d的患者有效率明显高于受伤至手术时间>7 d的患者(P<0.05)。结论全方位视神经管减压可改善无光感TON患者的视力,降低致盲率,是一种有效的手术治疗方法。
Objective To evaluate the clinical effect of total optic nerve canal decompression in the treatment of traumatic optic neuropathy(TON)without photoreceptor.Methods The clinical data of 67 patients with no photoreceptor TON admitted to Department of Neurosurgery of the Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine from January 2015 to December 2021 were selected for retrospective analysis,in which 37 cases in observation group received total optic nerve canal decompression surgery and 30 cases in control group received non-total optic nerve canal decompression surgery.Both groups received high-dose glucocorticoid therapy and oral administration of methylcobalamin before surgery.The visual acuity changes and complications after admission and treatment were examined and recorded in both groups.The effective rate,unblinding rate and complications after treatment were compared between the two groups.Results There were no statistically significant differences between observation group and control group in terms of age,gender,time from injury to surgery,preoperative GCS score,operative time,and intraoperative bleeding volume(P>0.05).After treatment,the effective rate of observation group was 54.1%and the unblinding rate was 35.1%,while the effective rate of control group was 46.7%and the unblinding rate was 33.3%;there was no statistically significant difference between the effective rate and unblinding rate of the two groups(P>0.05).No serious complications such as cerebrospinal fluid leakage,epilepsy,and intracranial infection occurred in both groups after surgery.In observation group,the effective rate after treatment was significantly lower in those with optic nerve canal fractures than that in those without optic nerve canal fractures(P<0.05);the effective rate was significantly higher in patients with injury-to-operation time≤7 d than that in patients with injury-to-operation time>7 d(P<0.05).Conclusion Total optic nerve canal decompression can improve the visual acuity of patients without photoreceptor TON and reduce the blinding rate,which is an effective surgical treatment method.
作者
李新宇
杨西涛
郭智霖
Li Xin-Yu;Yang Xi-Tao;Guo Zhi-Lin(Department of Neurosurgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medcine,Shanghai 201999,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2024年第2期177-181,共5页
Medical Journal of Chinese People's Liberation Army
基金
上海交通大学医学院附属第九人民医院基础研究助推计划(JYZZ076)。
关键词
外伤性视神经损伤
视神经管减压
治疗
预后
traumatic optic nerve injury
decompression of optic nerve canal
treatment
prognosis
