摘要
目的 观察补肾化痰通脉法干预颈动脉粥样硬化不稳定斑块的临床疗效。方法 选择2020年12月—2021年12月太仓市中医医院收治的78例明确诊断颈动脉不稳定斑块患者为研究对象,采用随机数字表法将其分成对照组和试验组,各39例。其中对照组予西药干预;试验组在对照组的基础上加入补肾化痰通脉颗粒。观察每组颈动脉粥样硬化不稳性斑块的变化,同时检测血脂指标水平以及评定中医证候积分并进行对比分析。结果 两组颈动脉内中膜厚度和最大斑块大小明显改善,但两组间的最大斑块面积差异无统计学意义(P>0.05);两组血脂水平均改善,且试验组优于对照组(P<0.05);两组中医证候积分均降低,且试验组明显优于对照组(P<0.05)。结论 补肾化痰通脉法可能通过改善患者颈动脉内中膜厚度、血脂水平,控制颈动脉粥样硬化病变的进展。
Objective To observe the clinical effect of tonifying kidney,eliminating phlegm and clearing vessels method in the intervention of carotid atherosclerotic unstable plaque.Methods A total of 78 patients with clearly diagnosed carotid unstable plaque admitted to Taicang Hospital of Traditional Chinese Medicine from December 2020 to December 2021 were selected as the research objects.They were divided into the control group and the experimental group by random number table method,with 39 cases in each group.The control group was treated with western medicine.The experimental group was treated with Bushen Huatan Tongmai granules on the basis of the control group.The changes of carotid atherosclerotic unstable plaque in each group were observed,and the levels of low-density lipoprotein,homocysteinemia and high-sensitivity C-reactive protein were detected.In addition,TCM syndrome integral and comparative analysis was carried out.Results Carotid intima-media thickness and maximum plaque size were significantly improved between the two groups,but there was no significant difference in maximum plaque area between the two groups(P>0.05).The blood lipid level of both groups was improved,and the experimental group was better than the control group(P<0.05).TCM syndrome scores of both groups were decreased,and the experimental group was significantly better than the control group(P<0.05).Conclusion Tonifying kidney,eliminating phlegm and clearing vessels method may control the progression of carotid atherosclerotic lesions by improving carotid intima-media thickness and low density lipoprotein.
作者
杨进平
袁磊
王敏玲
YANG Jinping;YUAN Lei;WANG Minling(Department of Encephalopathy,Taicang Hospital of Traditional Chinese Medicine,Jiangsu Province,Taicang 215400,China)
出处
《中国中医药现代远程教育》
2024年第8期105-108,共4页
Chinese Medicine Modern Distance Education of China
基金
苏州科技计划-民生科技医疗卫生应用基础研究项目【No.SYSD2020029】
江苏省太仓市科技计划-基础研究计划(医疗卫生应用基础研究)项目【No.TC2020JCYL12】。
关键词
眩晕
颈动脉不稳定斑块
肾虚痰瘀证
补肾化痰通脉法
dizziness
carotid unstable plaque
syndrome of kidney deficiency and phlegm stasis
tonifying kidney,eliminating phlegm and clearing vessels method
