摘要
目的探讨吗替麦考酚酯治疗系统性红斑狼疮的效果,为制订系统性红斑狼疮的临床治疗方案提供参考。方法选取2021年6月—2022年6月滕州市中心人民医院收治的系统性红斑狼疮患者80例为研究对象,并以电脑随机法分为对照组和观察组各40例。对照组实施泼尼松联合环磷酰胺治疗,观察组实施泼尼松联合吗替麦考酚酯治疗。比较两组治疗效果、药物不良反应发生率及治疗前后系统性红斑狼疮疾病活动度评分(SLEDAI)。结果治疗后,观察组治疗总有效率为97.50%,高于对照组的85.00%,差异有统计学意义(χ^(2)=3.913,P<0.05)。观察组药物不良反应发生率为7.50%,低于对照组的25.00%,差异有统计学意义(χ^(2)=4.500,P<0.05)。治疗前,两组SLEDAI评分比较,差异无统计学意义(P>0.05);治疗后,观察组SLEDAI评分为(5.82±0.78)分,低于对照组的(7.41±1.22)分,差异有统计学意义(t=6.944,P<0.05)。结论吗替麦考酚酯治疗系统性红斑狼疮效果良好,具有较高的安全性,值得临床推广应用。
Objective To investigate the effect of mycophenolate mofetil in the treatment of systemic lupus erythematosus,in order to provide reference for the development of clinical treatment plans for systemic lupus erythematosus.Methods A total of eighty patients with systemic lupus erythematosus admitted to Tengzhou Central People's Hospital from June 2021 to June 2022 were selected as the study subjects and were divided into control group and observation group with 40 cases in each group by using computer randomization method.The control group received prednisone combined with cyclophosphamide treatment,while the observation group received prednisone combined with mycophenolate mofetil treatment.The treatment effect,incidence of adverse drug reactions and systemic lupus erythematosus disease activity score(SLEDAI)before and after treatment of two groups were compared.Results After treatment,the total effective rate of treatment in the observation group was 97.50%,which was higher than 85.00%in the control group,and the difference was statistically significant(χ^(2)=3.913,P<0.05).The incidence of adverse drug reactions in the observation group was 7.50%,which was lower than that in the control group with 25.00%,and the difference was statistically significant(χ^(2)=4.500,P<0.05).Before treatment,there was no statistically significant difference in SLEDAI scores between the two groups(P>0.05);after treatment,the SLEDAI score of the observation group was(5.82±0.78)points,which was lower than that in the control group with(7.41±1.22)points,and the difference was statistically significant(t=6.944,P<0.05).Conclusion The treatment of systenic lupus erythematosus with mycophenolate mofetil had good effect and higher safety,and was worthy of clinical promotion and application.
作者
史然然
SHI Ran-ran(Rheumatology and Immunization Department,Tengzhou Central People's Hospital,Tengzhou Shandong Province 277599,China)
出处
《中国城乡企业卫生》
2024年第1期16-18,共3页
Chinese Journal of Urban and Rural Enterprise Hygiene
关键词
吗替麦考酚酯
系统性红斑狼疮
临床疗效
Mycophenolate mofetil
Systemic lupus erythematosus
Clinical efficacy
