摘要
目的 分析水陆二仙丹联合吗替麦考酚酯治疗儿童难治性肾病综合征(RNS)的疗效。方法 选取脾肾阳虚型儿童RNS患者80例,按照随机数字表法分为2组,对照组40例在诱导尿蛋白转阴后叠加吗替麦考酚酯维持治疗,研究组40例在对照组基础上加用水陆二仙丹。比较2组临床疗效、中医证候疗效、中医症状积分,并检测治疗前后的肾功能、血脂及炎症指标。结果 研究组临床疗效、中医证候疗效优于对照组(P<0.05)。治疗后,2组中医症状积分、血肌酐、尿素氮、24 h-UTP、TC、TG、IL-6、IL-17、TNF-α低于治疗前(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组的白蛋白高于治疗前(P<0.05),且研究组高于对照组(P<0.05)。结论 水陆二仙丹联合吗替麦考酚酯治疗脾肾阳虚型儿童RNS可提高疗效,改善肾功能与血脂紊乱,减轻炎症反应。
Objective To analyze the therapeutic effect of Shuilu Erxian mini-pill combined with mycophenolate mofetil on refractory nephrotic syndrome(RNS) in children.Methods Eighty children with RNS of spleen-kidney yang deficiency type from March 2021 to March 2022 were randomly divided into two groups according to the number table method.The control group consisted of 40 cases who received maintenance treatment with mycophenolate mofetil after inducing urinary protein to turn negative.The research group consisted of 40 cases who received Shuilu Erxian mini-pills based on the control group.The clinical efficacy,TCM syndrome efficacy,TCM symptom scores of the two groups,and detect renal function,blood lipids,and inflammatory indicators was compared before and after treatment.Results The clinical efficacy and TCM syndrome efficacy of the research group were better than those of the control group(P<0.05).After treatment,the TCM symptom scores,blood creatinine,urea nitrogen,24-hour UTP,TC,TG,IL-6,IL-17,and TNF-α of the two groups were lower than before treatment(P<0.05),and the research group were lower than the control group(P<0.05).After treatment,the albumin level in both groups was higher than before treatment(P<0.05),and the research group was higher than the control group(P<0.05).Conclusion The combination of Shuilu Erxian mini-pill and mycophenolate mofetil for children with RNS of spleen-kidney yang deficiency type can enhance the therapeutic effect,improve renal function and blood lipid disorders,and reduce inflammatory reactions.
作者
齐莎莎
孟凡威
张国伟
张旭亚
QI Shasha;MENG Fanwei;ZHANG Guowei;ZHANG Xuya(Department of Pediatrics,The First Affiliated Hospital of Henan University,Henan Province,Kaifeng 475001,China)
出处
《光明中医》
2024年第5期896-899,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
河南省开封市科技发展计划项目(No.2203031)。
关键词
水肿
难治性肾病综合征
儿童
水陆二仙丹
吗替麦考酚酯
edema
refractory nephrotic syndrome
children
Shuilu Erxian mini-pill
mycophenolate mofetil
