摘要
目的基于数据库相关数据分析人类白细胞抗原(HLA)-DQA1*0501和HLA-DQB1*02基因多态性与抗Ro/SSA抗体阳性的原发性干燥综合征(pSS)易感性的关系。方法使用计算机检索相关数据库,筛选并收集pSS患者、抗Ro/SSA抗体阳性的pSS患者、抗Ro/SSA抗体阴性的pSS患者以及健康对照人群的HLA-DQA1*0501、HLA-DQB1*02基因多态性资料。使用STATA 16.0(USA)统计软件分析抗Ro/SSA抗体阳性的pSS患者中HLA-DQA1*0501和HLA-DQB1*02基因多态性与pSS发生的关系。结果纳入文献5篇,涉及420例pSS患者、250例抗Ro/SSA抗体阳性pSS患者、120例抗Ro/SSA抗体阴性的pSS患者和733例健康对照者。在pSS患者中,HLA-DQA1*0501和HLA-DQB1*02基因阳性分别为159、246例;在健康对照者中,HLA-DQA1*0501和HLA-DQB1*02基因阳性分别为196、282例;在抗SSA抗体阳性pSS患者中,HLA-DQA1*0501和HLA-DQB1*02基因阳性分别为129、158例;在抗SSA抗体阴性pSS患者中,HLA-DQA1*0501和HLA-DQB1*02基因阳性分别为30、46例。HLA-DQA1*0501和HLA-DQB1*02基因多态性与pSS的易感性有关(I2分别为62.99%、40.75%,合计OR值分别为2.60、2.43,95%CI分别为1.49~4.55、1.88~3.14,P均<0.05)。HLA-DQA1*0501和HLA-DQB1*02基因多态性也与抗Ro/SSA抗体阳性pSS的易感性有关(I2分别为0.00%、9.41%,合计OR值分别为3.85、2.61,95%CI分别为1.81~8.21、1.52~4.48,P均<0.05)。结论HLA-DQA1*0501和HLA-DQB1*02基因多态性与抗Ro/SSA抗体阳性的pSS患者的易感性相关。具有HLA-DQA1*0501和HLA-DQB1*02基因阳性的抗Ro/SSA抗体阳性患者更容易患pSS。
Objective To investigate the correlation between human leukocyte antigen(HLA)-DQA1*0501 and HLA-DQB1*02 gene polymorphisms and susceptibility to primary Sjögren’s syndrome(pSS)in anti-Ro/SSA antibody-pos‐itive individuals using database-related data.Methods The study screened and collected the data of HLA-DQA1*0501 and HLA-DQB1*02 gene polymorphisms in patients with pSS who were positive or negative for anti-Ro/SSA antibodies,as well as in healthy controls,using a computerized search of relevant databases.The associations between HLA-DQA1*0501 and HLA-DQB1*02 gene polymorphisms and the occurrence of pSS in anti-Ro/SSA antibody-positive patients was ana‐lyzed using STATA 16.0(USA)statistical software.Results The study included five papers involving 420 patients with pSS,including 250 patients who tested positive for anti-Ro/SSA antibodies,120 patients who tested negative for anti-Ro/SSA antibodies,and 733 healthy controls.Of the pSS patients,159 and 246 cases tested positive for the HLA-DQA1*0501 and HLA-DQB1*02 genes,respectively.Among the healthy controls,196 and 282 cases tested positive for the HLA-DQA1*0501 and HLA-DQB1*02 genes,respectively.Among the pSS patients positive for anti-SSA antibodies,129 and 158 cases were positive for the HLA-DQA1*0501 and HLA-DQB1*02 genes,respectively.In the anti-SSA antibody-nega‐tive pSS patients,30 and 46 cases were positive for the HLA-DQA1*0501 and HLA-DQB1*02 genes,respectively.The study found that HLA-DQA1*0501 and HLA-DQB1*02 gene polymorphisms were associated with susceptibility to pSS(I2=62.99%and 40.75%,combined OR=2.60 and 2.43,95%CI=1.49-4.55 and 1.88-3.14,respectively;all P<0.05).The HLA-DQA1*0501 and HLA-DQB1*02 gene polymorphisms were also associated with susceptibility to anti-Ro/SSA an‐tibody-positive pSS(I2=0.00%and 9.41%,combined OR=3.85 and 2.61,95%CI=1.81-8.21 and 1.52-4.48,respec‐tively;all P<0.05).Conclusions HLA-DQA1*0501 and HLA-DQB1*02 gene polymorphisms are associated with sus‐ceptibility to pSS in individuals who test positive for anti-Ro/SSA antibodies.Specifically,patients with anti-Ro/SSA anti‐bodies and the HLA-DQA1*0501 and HLA-DQB1*02 genes are at higher risk of developing pSS.
作者
郑安昊
胡乃文
许婧
袁烨
张淑敏
陈文斌
白艳艳
孙红胜
ZHENG Anhao;HU Naiwen;XU Jing;YUAN Ye;ZHANG Shumin;CHEN Wenbin;BAI Yanyan;SUN Hongsheng(不详;Cheeloo College of Medicine,Shandong University,Jinan 250012,China)
出处
《山东医药》
CAS
2024年第6期44-48,共5页
Shandong Medical Journal
基金
国家自然科学基金资助项目(82070819)。
