摘要
目的探讨依达拉奉右莰醇联合甘露醇对初诊急性前循环大面积脑梗死(MCI)继发脑水肿患者神经功能的影响。方法选取医院神经内科2021年1月至2022年12月收治的MCI继发脑水肿患者110例,按随机数字表法分为观察组和对照组,各55例。两组患者均接受血管内介入取栓联合去骨瓣减压手术及常规抗血小板聚集、抗感染等对症治疗,并予甘露醇注射液静脉滴注,观察组患者加用依达拉奉右莰醇注射用浓溶液静脉滴注。两组均连续治疗15 d。结果观察组总有效率为83.64%,显著高于对照组的65.45%(P<0.05)。与对照组比较,观察组患者治疗后的脑水肿体积显著缩小,美国国立卫生研究院卒中量表(NIHSS)评分及改良Rankin量表(mRS)评分均显著降低(P<0.05),血清神经元特异性烯醇化酶、S100钙结合蛋白β、肿瘤坏死因子-α及白细胞介素1β水平均显著降低(P<0.05)。观察组与对照组不良反应发生率无显著差异(7.27%比12.73%,P>0.05)。结论依达拉奉右莰醇联合甘露醇治疗初诊急性前循环MCI继发脑水肿,能明显缩小脑水肿体积,改善神经功能,抑制炎性反应。
Objective To investigate the effects of edaravone and dexborneol combined with mannitol on the neurological function in patients with newly-diagnosed cerebral edema secondary to acute anterior-circulation massive cerebral infarction(MCI).Methods A total of 110 patients with cerebral edema secondary to MCI admitted to the Department of Neurology in the hospital from January 2021 to December 2022 were selected and divided into the observation group and the control group by the random number table method,with 55 cases in each group.The patients in the two groups were given intravascular thrombectomy combined with decompressive craniectomy and symptomatic treatment(such as conventional antiplatelet aggregation,anti-infection)and intravenous drip of Mannitol Injection,on this basis,the patients in the observation group were given intravenous drip of Edaravone and Dexborneol Concentrated Solution for Injection.Both groups were treated continuously for 15 d.Results The total effective rate in the observation group was 83.64%,which was significantly higher than 65.45%in the control group(P<0.05).Compared with those in the control group,the volume of cerebral edema,the National Institute of Health Stroke Scale(NIHSS)and modified Rankin Scale(mRS)scores in the observation group significantly decreased after treatment(P<0.05),the neuron-specific enolase(NSE),S100 calcium-binding proteinβ(S100β),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)levels significantly decreased(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(7.27%vs.12.73%,P>0.05).Conclusion Edaravone and dexborneol combined with mannitol can obviously decrease the volume of cerebral edema,improve neurological function,and inhibit inflammatory reaction in patients with newly-diagnosed cerebral edema secondary to acute anterior-circulation MCI.
作者
常勇
李莉
陈琳
曾超胜
CHANG Yong;LI Li;CHEN Lin;ZENG Chaosheng(The Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan,China 570311)
出处
《中国药业》
CAS
2024年第6期98-101,共4页
China Pharmaceuticals
基金
海南省重点研发项目[ZDYF2022SHFZ291]。
关键词
依达拉奉右莰醇
甘露醇
初诊
急性脑梗死
前循环
大面积脑梗死
脑水肿
神经功能
炎性反应
edaravone and dexborneol
mannitol
newly-diagnosed
acute cerebral infarction
anterior-circulation
massive cerebral infarction
cerebral edema
neurological function
inflammatory reaction
