摘要
自身免疫性甲状腺疾病是一种常见的自身免疫性疾病,发病率呈上升趋势,但其发病机制仍未明晰,临床在改善患者临床症状及提高生活质量方面仍有欠缺,网络药理学通过分析药物、靶点及疾病之间“多成分、多靶点、多途径”协同作用关系,目前已被应用于对自身免疫性甲状腺疾病的治疗指导。通过对相关文献进行分析,总结当前利用网络药理学方法进行中医药治疗自身免疫性甲状腺疾病的研究,阐明单药或者中药复方中的活性成分、作用靶点、生物过程及通路分析,为临床提供参考。此外,总结网络药理学的不足,以期中医药可以通过此法得到更好的发展。
Autoimmune thyroid disease is a common autoimmune disease with an increasing incidence,but its pathogenesis is still unclear,there are still some deficiencies in improving patients′clinical symptoms and quality of life.Network pharmacology analyzes the“multi-component-multi-target-multi-pathway”synergistic relationship among drugs,targets and diseases,it has been used to guide the treatment of autoimmune thyroid disease.Based on an analysis of the relevant literature,this paper summarized the current research on the treatment of autoimmune thyroid disease by traditional Chinese medicine using network pharmacological methods to clarify the active components,target,biological process and pathway analysis of single drug or compound Chinese medicine and provide reference for clinical practice.In addition,it summed up the deficiency of network pharmacology,so that Chinese medicine can be better developed through this method.
作者
邹晓琳
刘子玉
王智民
宋囡
高天舒
杨潇
ZOU Xiaolin;LIU Ziyu;WANG Zhimin;SONG Nan;GAO Tianshu;YANG Xiao(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第1期210-212,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
沈阳市中青年科技创新人才支持计划项目(RC200370)
辽宁省教育厅项目(L201923)
辽宁省科技厅自然基金项目(2019-MS-207)
国家自然基金青年基金项目(82104805)
国家自然科学基金青年基金项目(81503474)。
