摘要
目的探讨锦红汤加减联合西医治疗对急性胰腺炎患者炎症因子及凝血功能的影响。方法选取65例急性胰腺炎患者,随机分为对照组和观察组,比较治疗后腹痛缓解时间、腹胀缓解时间,肠鸣音恢复时间及首次排便时间;急性生理学与慢性健康状况评分系统Ⅱ(APACHE-Ⅱ)评分,中医证候积分,炎症指标及凝血功能的变化情况。结果治疗后两组组间比较,观察组在腹痛、痞满燥实坚、恶心呕吐、日晡潮热、口干口渴、小便短赤积分低于对照组,差异具有统计学意义(P<0.05)。观察组腹痛缓解时间、腹胀缓解时间及肠鸣音恢复时间和首次排便时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后组间比较,在C-反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白细胞(white blood cell,WBC)及血清淀粉酶(amylase,AMY)等方面水平均降低,且观察组降低水平低于对照组,差异具有统计学意义(P<0.05)。治疗后组间比较,在血小板计数(blood platelet,PLT)、D-二聚体(D-D)、凝血酶原时间(prothrombin time,PT)及部分活化凝血酶原时间(activated partialthromboplastin time,APTT)等凝血功能水平均有所改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后组间比较,观察组的APACHEⅡ评分显著低于对照组,差异具有统计学意义(P<0.05)。结论锦红汤加减联合西医治疗急性胰腺炎可抑制炎症反应,改善微循环,促进肠鸣音的恢复,缓解临床症状。
Objective To observe the effect of Jinhong Decoction(锦红汤)combined with western medicine on inflammatory factors and coagulation function in patients with acute pancreatitis.Methods Sixty-five patients with acute pancreatitis were randomly divided into observation group and control group.Both groups were treated with western medicine,and 33 cases in the observation group was given Jinhong Decoction(seven consecutive days).The abdominalgia relief time,the recovery time disappearance of abdominal tenderness,the recovery of bowel sounds,the first defecation time,the acute physiology and chronic health evaluation(APACHEⅡ)scores,traditional Chinese medicine(TCM)syndrome scores,C-reactive protein(CRP),procalcitonin(PCT),white blood cell(WBC)and amylase(AMY),activated partial thromboplastin time(APTT),prothrombin time(PT),platelet(PLT)and D-Dimer(D-D)were compared.Results After treatment,the scores of abdominal pain,full dryness,nausea and vomiting,respiratory fever,dry mouth thirst and short urinary deficit in the observation group were lower than those in the control group(P<0.05).After treatment,the abdominalgia relief time,the recovery time disappearance of abdominal tenderness,the first defecation time and the first defecation time in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of PCT,WBC,CRP and AMY in the observation group were lower than those of the control group(P<0.05).After treatment,the coagulation function indexes(PLT,D-D,PT and APTT)in the observation group were significantly superior to those in the control group(P<0.05).The APACHEⅡscore in the observation group was lower than that of the control group(P<0.05).Conclusion Compared with conventional western medicine alone,combined application of Jinhong Decoction can inhibit inflammatory reaction,improve microcirculation,promote the recovery of bowel sound and relieve clinical symptoms.
作者
梅丹
王伟
周伟科
葛晓军
李廷
余奎
杨吉勇
叶圳
顾宏刚
张静喆
MEI Dan;WANG Wei;ZHOU Weike;GE Xiaojun;LI Ting;YU Kui;YANG Jiyong;YE Zhen;GU Honggang;ZHANG Jingzhe(Jinshan Branch of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China;Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第2期99-102,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(青年)项目(82004372)
金山区普外科专家工作站项目(JSZJZ2020028Y)
金山区卫生健康委员会项目(J-KTQN-2020)。
关键词
锦红汤
急性胰腺炎
炎症因子
凝血功能
Jinhong Decoction(锦红汤)
acute pancreatitis
coagulation function
inflammatory factor
