摘要
目的探讨血清同型半胱氨酸(HCY)、C反应蛋白(CRP)和乳酸脱氢酶(LDH)在鼻咽癌患者中的水平及意义。方法选择2021年12月至2022年7月梧州市红十字会医院收治的222例初诊鼻咽癌患者为鼻咽癌组,102例鼻咽炎患者为鼻咽炎组,100例体检健康者为对照组。比较各组受试者血清HCY、CRP及LDH水平。采用Spearman相关分析患者血清HCY、CRP及LDH水平与TNM分期的相关性。结果鼻咽癌组血清HCY水平明显高于鼻咽炎组、对照组(P<0.001)。鼻咽炎组、鼻咽癌组患者血清CRP水平高于对照组(P<0.001),而鼻咽炎组与鼻咽癌组间CRP水平比较,差异无统计学意义(P>0.05)。各组间血清LDH水平比较,差异均无统计学意义(P>0.05)。不同TNM分期鼻咽癌患者血清HCY、CRP及LDH水平比较,差异有统计学意义(P<0.05);Ⅲ期患者血清HCY水平明显高于Ⅰ~Ⅱ期(P<0.05),CRP水平明显低于ⅣB期(P<0.05);ⅣA、ⅣB期患者血清HCY、CRP及LDH水平明显高于Ⅰ~Ⅱ期(P<0.05)。Spearman相关分析显示,鼻咽癌患者血清CRP、LDH水平与TNM分期呈正相关(r=0.231、0.212,P<0.01),但HCY水平与TNM分期无相关性(P>0.05)。结论鼻咽癌患者伴有血清HCY、CRP水平的升高,TNM分期Ⅳ期患者HCY、CRP及LDH水平明显升高。
Objective To explore the levels and significance of serum homocysteine(HCY),C-reactive protein(CRP) and lactate dehydrogenase(LDH) in the patients with nasopharyngeal carcinoma.Methods A total of 222 patients with newly diagnosed nasopharyngeal carcinoma admitted and treated in this hospital from December 2021 to July 2022 were included in the nasopharyngeal carcinoma group,102 patients with nasopharyngeal inflammation served as the nasopharyngeal inflammation group,and 100 healthy individuals undergoing physical examination served as the control group.The serum HCY,CRP,and LDH levels were compared among the groups.The correlation between serum HCY,CRP and LDH levels with the TNM stage was analyzed by Spearman correlation.Results The serum HCY level in the nasopharyngeal carcinoma group was significantly higher than that in the nasopharyngeal inflammation group and control group(P<0.001).The serum CRP level in the nasopharyngeal inflammation group and nasopharyngeal carcinoma group was higher than that in the control group(P<0.001),while there was no statistically significant difference in the CRP level between the nasopharyngeal inflammation group and nasopharyngeal carcinoma group(P>0.05).There was no statistically significant difference in serum LDH level among the groups(P>0.05).The levels of serum HCY,CRP and LDH had statistical difference among the patients with different TNM stages of nasopharyngeal carcinoma(P<0.05).The serum HCY level in the patients with TNM Ⅲ stage was significantly higher than that in the patients with TNM Ⅰ-Ⅱ stage(P<0.05),and the CRP level was significantly lower than that in the patients with ⅣB stage(P<0.05).The levels of serum HCY,CRP and LDH in the patients with TNM ⅣA stage and ⅣB stage were significantly higher than those in the patients with stage Ⅰ-Ⅱ(P<0.05).Spearman correlation analysis showed that serum CRP and LDH levels were positively correlated with the TNM stage(r=0.231,0.212,P<0.01),but the HCY level had no correlation with the TNM stage(P>0.05).Conclusion The serum HCY and CRP levels are increased in the patients with nasopharyngeal carcinoma,and the HCY,CRP and LDH levels in the patients with TNM Ⅳ stage are significantly elevated.
作者
陈秀勤
潘美秀
蒙秀坚
麦莹莹
汤敏中
CHEN Xiuqin;PAN Meixiu;MENG Xiujian;MAI Yingying;TANG Minzhong(Department of Clinical Laboratory,Wuzhou Municipal Red Cross Hospital of Guangxi Zhuang Autonomous Region,Wuzhou,Guangxi 543000,China)
出处
《检验医学与临床》
2024年第6期766-769,共4页
Laboratory Medicine and Clinic
基金
国家自然科学基金项目(81860503)
广西壮族自治区梧州市科技计划项目(202102065)。
关键词
鼻咽癌
同型半胱氨酸
C反应蛋白
乳酸脱氢酶
临床分期
nasopharyngeal carcinoma
homocysteine
C-reactive protein
lactate dehydrogenase
clinical stage
