摘要
目的探讨术前白蛋白/铁蛋白比值表达与晚期胃癌根治性术后早期腹腔出血发生的关系。方法采用病例对照研究,收集河南省信阳市中心医院于2021年2月至2022年11月收治的22例行胃癌根治性切除术后早期发生腹腔出血的晚期胃癌患者临床资料,纳入发生组,另收集医院同期44例未发生术后早期腹腔出血的晚期胃癌患者临床资料,纳入未发生组。通过查阅晚期胃癌患者病历和随访资料,记录年龄、性别、原发灶部位、疾病类型、手术时间等基线资料;收集术前测量白蛋白、铁蛋白、癌胚抗原(CEA)、糖类抗原(CA199)、糖化血红蛋白、总胆固醇等水平,并计算白蛋白/铁蛋白值。分析白蛋白/铁蛋白水平与晚期胃癌根治术后早期腹腔出血发生的关系。结果发生组白蛋白、白蛋白/铁蛋白明显低于未发生组(P<0.05);组间年龄、性别、疾病类型、原发灶部位等基线资料和其他实验室指标比较差异无统计学意义(P>0.05);经点二列相关结果显示,白蛋白、白蛋白/铁蛋白与晚期胃癌根治术后早期腹腔出血发生间呈负相关(r<0,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示,术前白蛋白/铁蛋白预测晚期胃癌根治术后早期腹腔出血发生情况的AUC值为0.723,具有一定预测效能。结论白蛋白/铁蛋白与晚期胃癌根治术后早期腹腔出血发生有关,白蛋白/铁蛋白值越小,术后腹腔出血可能性越大。
【Objective】To investigate the relationship between the expression of albumin/ferritin ratio before operation and the occurrence of early abdominal hemorrhage after radical surgery for advanced gastric cancer.【Methods】A case-control study was conducted,the clinical data of 22 patients with advanced gastric cancer who underwent early abdominal hemorrhage after radical gastrectomy in Xinyang Central Hospital of Henan Province from February 2021 to November 2022 were collected and included into the occurrence group.In addition,the clinical data of 44 patients with advanced gastric cancer who did not have early postoperative abdominal hemorrhage during the same period were collected and included in the non-occurrence group.By consulting the medical records and follow-up data of patients with advanced gastric cancer,the baseline data such as age,sex,primary lesion location,disease type,and operation time were recorded.The levels of albumin,ferritin,carcinoembryonic antigen(CEA),carbohydrate antigen(CA199),glycosylated hemoglobin and total cholesterol were measured before operation,and the albumin/ferritin value was calculated.The relationship between the level of albumin/ferritin and the occurrence of early abdominal hemorrhage after radical resection of advanced gastric cancer was analyzed.【Results】Albumin and albumin/ferritin in the occurrence group were significantly lower than those in the non-occurrence group,with a statistical significant difference(P<0.05).There was no statistical significant difference in the baseline data of age,sex,disease type,primary focus and other laboratory indicators between the groups(P>0.05).The results of point two column correlation showed that albumin and albumin/ferritin were negatively correlated with early abdominal hemorrhage after radical gastrectomy for advanced gastric cancer(r<0,P<0.05).The ROC curve was drawn.The results showed that the AUC value of preoperative albumin/ferritin in predicting the occurrence of early abdominal hemorrhage after radical resection of advanced gastric cancer was 0.723,which had certain predictive power.【Conclusion】Albumin/ferritin is associated with early abdominal hemorrhage after radical resection of advanced gastric cancer.The lower the albumin/ferritin value,the greater the possibility of postoperative abdominal hemorrhage.
作者
肖雷
蒋亚新
许家亮
李海春
XIAO Lei;JIANG Yaxin;XU Jialiang;LI Haichun(Department of Surgical Oncology,Xinyang Central Hospital of Henan Province,Xinyang,Henan 464200,China)
出处
《中国医学工程》
2024年第3期83-87,共5页
China Medical Engineering
关键词
胃癌
腹腔出血
白蛋白
铁蛋白
gastric cancer
abdominal hemorrhage
albumin
ferritin
