摘要
目的探讨复方苦参注射液用于恶性肿瘤患者的临床疗效及其对放疗后骨髓抑制及相关不良反应的影响。方法选取2019年10月至2023年2月安徽胸科医院恶性肿瘤患者85例,随机分为对照组(44例)和治疗组(41例)。对照组采用常规放疗疗法,治疗组在对照组的基础上给予复方苦参注射液治疗,比较两组患者的临床疗效、骨髓抑制发生情况、血常规检查及不良反应发生情况。结果85例患者中男72例,女13例,年龄36~81岁,平均(62.9±9.3)岁。治疗组总有效率高于对照组(51.2%比29.5%);治疗组治疗第2周WBC、中性粒细胞计数高于对照组[(7.1±3.1)×109/L比(5.6±2.9)×109/L,(5.9±3.0)×109/L比(4.3±2.6)×109/L],第2周和第4周PLT低于对照组[(168.2±52.4)×109/L比(226.1±87.0)×109/L,(137.5±55.8)×109/L比(182.0±87.1)×109/L];治疗组放射性肺炎发生率低于对照组(2.4%比22.7%),差异均有统计学意义(P<0.05)。结论复方苦参注射液联合放疗可提高恶性肿瘤患者的临床疗效,降低放射性肺炎发生率,安全性较高。
Objective To explore the clinical efficacy of compound Kushen injection in patients with malignant tumors and its influence on bone marrow suppression and related adverse reactions after radiotherapy.Methods A total of 85 patients with malignant tumors in Anhui Chest Hospital from October 2019 to February 2023 were selected,and were randomly divided into control group(44 cases)and treatment group(41 cases).The control group was treated with conventional radiotherapy,while the treatment group was treated with compound Kushen injection on the basis of the control group.The clinical efficacy,bone marrow suppression,blood routine examination and adverse reactions were compared between the two groups.Results Among 85 patients,there were 72 males and 13 females,aged from 36 to 81 years old,with an average age of(62.9±9.3)years.The total effective rate of the treatment group was higher than that of the control group(51.2%vs.29.5%).The WBC and neutrophil count level at the second week in the treatment group were higher than those in the control group[(7.1±3.1)×109/L vs.(5.6±2.9)×109/L,(5.9±3.0)×109/L vs.(4.3±2.6)×109/L],and the PLT level at the second week and the fourth week were lower than those in the control group[(168.2±52.4)×109/L vs.(226.1±87.0)×109/L,(137.5±55.8)×109/L vs.(182.0±87.1)×109/L].The incidence of radiation pneumonitis in the treatment group was lower than that in the control group(2.4%vs.22.7%),and the difference was statistically significant(P<0.05).Conclusions Compound Kushen injection combined with radiotherapy can improve the clinical efficacy of patients with malignant tumor,reduce the incidence of radiation pneumonia,and with high safety.
作者
王安帮
王伟
徐玲玲
Wang Anbang;Wang Wei;Xu Lingling(The Second Department of Oncology,Anhui Chest Hospital,Hefei 230022,China)
出处
《北京医学》
CAS
2023年第12期1074-1078,共5页
Beijing Medical Journal
基金
国家中药标准化项目(ZYBZH-C-JIN-43)。
关键词
复方苦参注射液
恶性肿瘤
放疗
骨髓抑制
不良反应
compound Kushen injection
malignant tumors
radiotherapy
bone marrow suppression
adverse reactions
