摘要
目的分析铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型幽门螺杆菌(Hp)感染性胃溃疡的临床疗效。方法选取2020年1月至2021年12月河南科技大学第一附属医院收治的80例脾胃虚寒型Hp感染性胃溃疡患者作为研究对象,按照不同治疗方法将其分为联合组(40例)与对照组(40例),联合组患者采用铋剂四联疗法联合针刺督脉背段压痛穴位治疗,对照组患者单纯采用铋剂四联疗法治疗,对比观察两组患者中医症候评分、溃疡长径、血清胃泌素(GAS)水平、Hp转阴率及临床疗效。结果治疗14 d后,联合组患者胃脘疼痛、食后腹胀、嗳气泛酸、恶心反胃评分以及血清GAS水平均明显低于对照组(t=6.910、6.318、7.140、9.345、8.819,P均<0.001),溃疡长径明显短于对照组(t=18.860,P<0.001);联合组患者Hp转阴率为87.5%,明显高于对照组患者的Hp转阴率67.5%(χ^(2)=4.588,P=0.032);联合组患者中显效26例、有效11例、无效3例,明显优于对照组患者的显效19例、有效10例、无效11例(Z=-1.997,P=0.046)。结论铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型Hp感染性胃溃疡,可明显降低GAS水平,提高Hp转阴率,改善患者脾胃虚寒症状,促进溃疡愈合。
Objective To analyze the clinical efficacy of bismuth quadruple therapy combined with acupuncture on tender point of dorsal segment of governor vessel in the treatment of Helicobacter pylori(Hp)infected gastric ulcer of spleen and stomach deficiency-cold syndrome.Methods 80 patients with Hp-infected gastric ulcer of spleen and stomach deficiency-cold syndrome,admitted to The First Affiliated Hospital of Henan University of Science and Technology from January 2020 to December 2021,were enrolled as research subjects and divided,based on the treatments they received,into combination group(n=40)and control group(n=40).Patients in the combination group were treated with bismuth quadruple therapy combined with acupuncture on tender point of dorsal segment of governor vessel,while patients in the control group were treated with bismuth quadruple therapy alone.The TCM syndrome scores,ulcer long diameter,serum gastrin(GAS)levels,Hp negative conversion rate and clinical efficacy were compared between the two groups.Results After 14 days of treatment,the scores of epigastric pain,postprandial abdominal distension,belching and acid regurgitation,nausea,and serum GAS level of patients in the combination group were all significantly lower than those in the control group(t=6910,6318,7140,9345 and 8819,all P<0001).Compared with the control group,the ulcer long diameter of patients in the combination group was significantly shorter(t=18860,P<0001).Hp negative conversion rate of patients in the combination group was 875%,being significantly higher than 675%in the control group(χ^(2)=4588,P=0032).In the combination group,26 cases were markedly effective,11 cases were effective and 3 cases were ineffective,which was obviously superior to the control group(Z=-1997,P=0046)in which 19 cases were markedly effective,10 cases were effective and 11 cases were ineffective.Conclusion Bismuth quadruple therapy combined with acupuncture on tender point of dorsal segment of governor vessel in the treatment of Hp-infected gastric ulcer of spleen and stomach deficiency-cold syndrome can significantly reduce the level of GAS,improve the Hp negative conversion rate,improve the spleen and stomach deficiency-cold symptoms of patients,and promote ulcer healing.
作者
王小沙
刘青塬
WANG Xiaosha;LIU Qingyuan(Department of Rehabilitation Medicine,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000,China)
出处
《中国烧伤创疡杂志》
2024年第2期152-156,共5页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
针刺
督脉背段
压痛穴位
铋剂四联疗法
Hp感染
胃溃疡
脾胃虚寒
Acupuncture
Dorsal segment of the governor vessel
Tender point
Bismuth quadruple therapy
Hp infection
Gastric ulcer
Spleen and stomach deficiency-cold
