摘要
目的:观察脓毒症性心肌功能障碍患者接受血必净注射液干预的有效性。方法:选取2021年3月—2023年3月贵州省人民医院收治的脓毒症心肌功能障碍患者92例作为研究对象,以随机数字表法分为普通干预组和实践干预组,各46例。普通干预组采用基础抗感染及抗休克治疗,实践干预组在对照组基础上给予血必净注射液治疗。比较两组患者ICU治疗时间、心功能与血浆脑钠尿肽、血清炎性因子与肾功能、治疗有效率。结果:实践干预组ICU治疗时间短于普通干预组,差异有统计学意义(P=0.035);干预后,两组左心室舒张末期内径、左室射血分数、每分心输出量与血浆脑钠尿肽均优于干预前,实践干预组优于普通干预组,差异有统计学意义(P<0.05);干预后,实践干预组白细胞介素-10、白细胞介素-6、肿瘤坏死因子-α、白蛋白及血肌酐均优于普通干预组,差异有统计学意义(P<0.05);实践干预组治疗有效率高于普通干预组,差异有统计学意义(P=0.001)。结论:脓毒症性心肌功能障碍的临床治疗中应用血必净注射液干预效果显著,可有效改善患者心功能、肾功能、炎性因子,降低血浆脑钠尿肽水平,促进康复。
Objective:To observe the effectiveness of Xuebijing injection in patients with sepsis myocardial dysfunction.Methods:Ninety-two patients with myocardial dysfunction of sepsis admitted to Guizhou Provincial People's Hospital from March 2021 to March 2023 were selected as the study objects,and were divided into general intervention group and practical intervention group by random number table method,with forty-six cases in each group.The general intervention group was treated with basic antiinfection and anti-shock therapy,and the practical intervention group was treated with Xuebijing injection on the basis of control group.ICU treatment time,cardiac function,plasma brain natriuretic peptide,serum inflammatory factors and renal function,and treatment effectiveness were compared between the two groups.Results:The duration of ICU treatment in practical intervention group was shorter than that in general intervention group,and the difference was statistically significant(P=0.035);After interven⁃tion,left ventricular end-diastolic diameter,left ventricular ejection fraction,output per distraction and plasma brain natriuretic peptide in two groups were better than before intervention,and the practical intervention group was better than the general interven⁃tion group,the difference was statistically significant(P<0.05);After intervention,interleukin-10,interleukin-6,tumor necrosis fac⁃tor-α,albumin and serum creatinine in practical intervention group were better than those in general intervention group,the differ⁃ence was statistically significant(P<0.05);The total effective rate of the practical intervention group was higher than that of the gen⁃eral intervention group,and the difference was statistically significant(P=0.001).Conclusion:In the clinical treatment ofmyocardial dysfunction of sepsis,the intervention effect of Xuebijing injection is significant,which can effectively improve the heart function,kidney function,inflammatory factors,reduce the level of plasma brain natriuretic peptide,and promote their rehabilitation.
作者
孙鸿鹏
Sun Hongpeng(Department of Emergency Medicine,Guizhou Provincial People's Hospital,Guiyang 550000,Guizhou Province,China)
出处
《中外医药研究》
2024年第1期84-86,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
血必净注射液
脓毒症
心肌功能障碍
心功能
炎性因子
Xuebijing injection
Sepsis
Myocardial dysfunction
Heart function
Inflammatory factor
