摘要
目的应用网状Meta分析手段评价多种常见中药注射液对癌因性疲乏的疗效差异。方法系统检索建库至2022年9月收录在PubMed、Web of Science、Cochrane Library、中国知网、万方数据库、中国生物医学文献数据库和中国科技期刊数据库中的相关随机对照试验,经文献筛选及质量评价后,采用stata17.0进行数据分析。结果最终纳入18篇文献,涉及1404例患者、6种中药注射液。结果显示:①化疗阶段:康艾注射液[均数差(mean deviation,MD)=-2.30,95%置信区间(confidence interval,CI)(-3.09,-1.52)]、艾迪注射液[MD=-1.31,95%CI(-1.99,-0.62)]联合化疗优于单纯化疗,概率排序第1为康艾注射液[MD=-1.05,95%CI(-1.89,-0.21)];②姑息治疗阶段:参麦注射液[MD=-1.24,95%CI(-1.91,-0.57)]、康艾注射液[MD=-1.02,95%CI(-1.65,-0.39)]、参芪扶正注射液[MD=-0.54,95%CI(-0.90,-0.19)]联合姑息治疗优于单纯姑息治疗,概率排序第1为参麦注射液[MD=-1.26,95%CI(-2.15,-0.37)]。结论4种中药注射液治疗CRF有效,其中,化疗期间使用康艾注射液效果更佳,姑息治疗期间使用参麦注射液效果更佳。
Objective Network Meta-analysis was conducted to evaluate the differences in the efficacy of different traditional Chinese medicine injections(TCMI)in patients with cancer-related fatigue.Methods The database was systematically searched and included in Cochrane Library,PubMed,Web of Science,CNKI,Wan Fang,China Biomedical Literature Database and Database of Chinese sci-tech periodicals until September,2022.These relevant randomized controlled trial literatures were evaluated the methodological quality by using of Cochrane risk of bias assessment tool.Results 18 articles involving 1404 patients and 6 traditional Chinese medicine injections(TCMI)were included.The results showed that Kangai injection[MD=-2.30,95%CI(-3.09,-1.52)]and Aidi injection[MD=-1.31,95%CI(-1.99,-0.62)]combined with chemotherapy were better than chemotherapy alone in improving CRF in cancer patients during chemotherapy,among which Kangai injection is more effective[MD=-1.05,95%CI(-1.89,-0.21)];Shenmai injection[MD=-1.24,95%CI(-1.91,-0.57)],Kangai injection[MD=-1.02,95%CI(-1.65,-0.39)],and Shenqifuzheng injection[MD=-0.54,95%CI(-0.90,-0.19)]were superior to palliative care alone in improving CRF in palliative care of cancer patients,among which Shenmai injection[MD=-1.26,95%CI(-2.15,-0.37)]is more effective.Conclusions The results demonstrated that TCMI can improve the degree of cancer-related fatigue in tumor patients at different stages.When combined with chemotherapy,Kangai injection was superior to other TCMI,while when combined with palliative treatment,Shenmai injection was superior to other TCMI.
作者
许可依
胡凯文
孙健豪
吴娇
崔宁
李刘生
吴煜
Xu Keyi;Hu Kaiwen;Sun Jianhao;Wu Jiao;Cui Ning;Li Liusheng;Wu Yu(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Graduate School of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第12期4017-4031,共15页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
中国中医科学院科技创新工程肿瘤学重大攻关项目(CI2021A01803):健脾化痰方治疗晚期结直肠癌的疗效及优势人群和甲基化特征研究,负责人:吴煜
中国中医科学院西苑医院苗圃课题(2019XYMP--24):“十味益元颗粒”治疗癌因性疲乏随机、双盲的疗效和机制研究,负责人:崔宁
中国中医科学院科技创新工程(CI2021A01815):基于KDM2B/PI3K/AKT探讨健脾化痰方通过调节肿瘤干细胞干性特征预防结直肠癌转移的机制研究,负责人:郝腾腾。
关键词
癌因性疲乏
中药注射液
网状Meta分析
化疗
Cancer-related fatigue
Traditional Chinese medicine injection
Network meta-analysis
Chemotherapy
