摘要
目的探讨超声、MRI及肿瘤标志物联合检查对卵巢良恶性肿瘤的鉴别诊断价值。方法选取80例卵巢肿瘤患者,所有患者均进行超声、MRI及肿瘤标志物检查。根据术后病理检查结果将患者分为良性组(n=50)和恶性组(n=30)。比较两组患者的超声图像特征、MRI影像学表现及肿瘤标志物[糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)、糖类抗原125(CA125)及癌胚抗原(CEA)]水平。分析超声、MRI、肿瘤标志物单独及联合检查对卵巢恶性肿瘤的诊断价值。结果超声检查显示,恶性组中肿瘤形态不规则、回声不均匀、无包膜比例均明显高于良性组,恶性组患者血流阻力指数明显低于良性组,差异均有统计学意义(P﹤0.01)。MRI检查显示,恶性组中肿瘤形态不规则、双侧分布、实性或囊实性成分、边界不清晰比例均明显高于良性组,差异均有统计学意义(P﹤0.01)。恶性组患者CA125、CA19-9、AFP、CEA水平均明显高于良性组,差异均有统计学意义(P﹤0.01)。超声、MRI、肿瘤标志物联合检查诊断卵巢恶性肿瘤的灵敏度、特异度、准确度、阳性预测值和阴性预测值均高于三者单独检查。结论超声、MRI、肿瘤标志物联合检查对卵巢恶性肿瘤具有较高的诊断价值。
Objective To investigate the value of ultrasound,MRI,and tumor markers combined detection in the differential diagnosis of ovarian benign and malignant tumors.Method A total of 80 patients with ovarian tumor were selected,all patients received ultrasound,MRI and tumor markers detection.The patients were divided into benign group(n=50)and malignant group(n=30)according to postoperative pathological examination results.The ultrasound image characteristics,MRI imaging findings and tumor markers[carbohydrate antigen 19-9(CA19-9),alpha-fetal protein(AFP),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)]of the two groups were compared.The diagnostic value of ultrasound,MRI and tumor markers single and combined detection for ovarian malignant tumor were analyzed.Result Ultrasound showed that the proportions of tumor irregular shape,uneven echo and no envelope in the malignant group were significantly higher than those in the benign group,and the blood flow resistance index in the malignant group was significantly lower than that in the benign group,and the differences were statistically significant(P<0.01).MRI showed that the proportions of tumor irregular shape,bilateral distribution,solid or solid-cystic components,and unclear boundary in the malignant group were significantly higher than those in the benign group,and the differences were statistically significant(P<0.01).The levels of CA125,CA19-9,AFP and CEA in the malignant group were significantly higher than those in the benign group,and the differences were statistically significant(P<0.01).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of ultrasound,MRI and tumor markers combined detection in the diagnosis of ovarian malignant tumor were higher than those of the single detection.Conclusion Ultrasound,MRI and tumor markers combined detection has higher diagnostic value for ovarian malignant tumor.
作者
程琳
邓秀娟
张茜
CHENG Lin;DENG Xiujuan;ZHANG Qian(Department of Functional Diagnostic,Maternal and Child Health Hospital of Jiujiang City,Jiujiang 332000,Jiangxi,China)
出处
《癌症进展》
2024年第2期172-175,共4页
Oncology Progress
基金
江西省卫生健康委科技计划项目(202211905)。
关键词
超声
MRI
肿瘤标志物
卵巢癌
诊断价值
ultrasound
MRI
tumor marker
ovarian cancer
diagnostic value
