摘要
认知功能障碍是2型糖尿病(T2DM)的常见并发症。脑微血管功能障碍是T2DM认知功能障碍的发病机制之一,脑小血管病(CSVD)是其主要表现形式。目前常采用MRI技术检测CSVD,包括常规MRI、扩散加权成像(DWI)、磁敏感加权成像(SWI)等。CSVD的MRI特征包括腔隙性梗死、脑白质高信号(WMH)、脑微出血(CMB)、血管周围间隙扩大(EPVS)、脑萎缩等,这些MRI特征与T2DM认知功能障碍密切相关。综述T2DM伴CSVD认知功能障碍的发病机制及MRI研究进展。
Cognitive dysfunction is a common complication of type 2 diabetes(T2DM).Cerebral microvascular dysfunction is one of the pathogeneses of cognitive impairment in T2DM,with cerebral small vessel disease(CSVD)being its main manifestation.Currently,MRI is a common technology for detecting CSVD,including conventional MRI,diffusion weighted imaging,susceptibility weighted imaging,etc.The MRI features of CSVD include lacunar infarction,white matter hyperintensity,cerebral microbleeds,enlarged perivascular spaces,and cerebral atrophy.These MRI features are closely related to cognitive dysfunction in T2DM.This review explores the pathogenesis and MRI research progress of cognitive impairment in T2DM with CSVD.
作者
代盼
于瀛
崔光彬
颜林枫(审校)
DAI Pan;YU Ying;CUI Guangbin;YAN Linfeng(Graduate Work Department of Xi’an Medical University,Xi’an 710068,China;Department of Radiology,Tangdu Hospital,Air Force Medical University)
出处
《国际医学放射学杂志》
2024年第2期195-198,共4页
International Journal of Medical Radiology
基金
国家自然科学基金(82302148)
陕西省重点研发计划项目(2023-YBSF-331)
陕西省自然科学基础研究计划项目(2024JC-ZDXM-41)。
关键词
2型糖尿病
脑小血管病
认知功能障碍
脑微血管功能障碍
Type 2 diabetes mellitus
Cerebral small vessel disease
Cognitive dysfunction
Cerebral microvascular dysfunction
