摘要
目的 观察坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片复合包装对围绝经期综合征(PMS)患者性激素的影响。方法 选取2019年1月—2022年12月昆山市第一人民医院收治的103例PMS患者作为研究对象,根据治疗方案将患者分为A组35例和B组68例。A组患者服用雌二醇片/雌二醇地屈孕酮片复合包装治疗,B组患者在A组基础上联合坤泰胶囊治疗,2组均连续用药12周。比较2组用药前后性激素指标[雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)]、匹兹堡睡眠质量指数(PSQI)评分,症状/体征改善效果及药物相关不良反应。结果 用药12周后,2组E2水平高于用药前,FSH、LH水平及睡眠质量、睡眠时间、睡眠障碍评分低于用药前,且B组高/低于A组(P<0.01)。B组症状/体征改善总有效率高于A组(88.24%vs. 71.43%,χ^(2)=4.530,P=0.033)。治疗期间,B组药物相关不良反应总发生率低于A组(13.24%vs.31.43%,χ^(2)=4.890,P=0.027)。结论 坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片复合包装治疗PMS患者可更有效地纠正性激素异常分泌,调节性激素表达水平,从而改善患者的临床症状,且安全性较高。
Objective To analyze the effect of Kuntai capsules combined with complex packing estradiol tablets/estradiol and dydrogesterone tablets on sex hormone in patients with PMS.Methods A total of 103 patients with PMS were selected in the First People′s Hospital of Kunshan from January 2019 to December 2022,and they were divided into the group A with 35 cases and the group B with 68 cases by the medication plan.Patients in the group A were given complex packing estradiol tablets/estradiol and dydrogesterone tablets,and patients in the group B were given Kuntai capsules based on group A,both groups were treated for 12 weeks.Sex hormone indexes(E 2,FSH,LH),PSQI score before and after medication,improvement effect of symptoms/signs and drug-related adverse reactions were compared between the two groups.Results After 12 weeks of medication,E 2 level of the two groups was higher than that before medication,levels of FSH,LH and scores of sleep quality,sleep time,sleep disorder were lower than those before medication,and the group B were higher/lower than those of group A(P<0.01).Total effective rate of symptom/sign improvement of the group B was higher than that of the group A(88.24%vs.71.43%,χ2=4.530,P=0.033).During treatment,incidence of drug-related adverse reactions of the group B was lower than that of the group A(13.24%vs.31.43%,χ2=4.890,P=0.027).Conclusion Kuntai capsules combined with complex packing estradiol tablets/estradiol and dydrogesterone tablets can more effectively correct abnormal secretion of sex hormone,regulate the expression level of sex hormone,thus improve the clinical symptoms of patients,and with higher safety.
作者
徐玲玲
吴梦
孙静
XU Lingling;WU Meng;SUN Jing(Department of Pharmacy,the First People′s Hospital of Kunshan,Jiangsu Province,Kunshan 215300,China)
出处
《临床合理用药杂志》
2024年第9期40-43,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
围绝经期综合征
坤泰胶囊
雌二醇片/雌二醇地屈孕酮片复合包装
性激素
Perimenopausal syndrome
Kuntai capsules
Complex packing estradiol tablets/estradiol and dydrogesterone tablets
Sex hormone
