摘要
目的分析β_(2)微球蛋白(β_(2)-microglobulin,β_(2)-MG)、血清胱抑素(cystatin C,CysC)与尿微量白蛋白/尿肌酐比值(Albumin-to-creatinine Ratio,ACR)在早期糖尿病肾病诊断中的诊断价值。方法选取2021年1月—2022年12月江苏省灌云县中医院检验科收治的46例单纯糖尿病为观察A组,54例糖尿病肾病患者为观察B组,并以同时期到本院体检的56例体检者为对照组,均测定β_(2)-MG、CysC与ACR水平,分析其在早期糖尿病肾病中的诊断效果。结果观察组β_(2)-MG为(3.56±0.42)mg/L、CysC为(1.23±0.38)mg/L与ACR为(70.24±43.73)mg/g高于对照组的(2.11±0.41)mg/L、(0.61±0.21)mg/L、(10.65±7.55)mg/g,差异有统计学意义(t=20.861、11.273、10.100,P均<0.05)。观察B组β_(2)-MG、CysC与ACR水平高于观察A组,差异有统计学意义(P均<0.05)。联合检测的灵敏度、特异度及准确度高于β_(2)-MG、CysC与ACR单一检测,差异有统计学意义(P均<0.05)。结论β_(2)-MG、CysC与ACR指标可作为早期糖尿病肾病患者诊断的敏感指标,对患者病情诊断、治疗方案拟定及预后评估有重要意义。
Objective To analyze the diagnostic value ofβ_(2)-microglobulin(β_(2)-MG),cystatin C(CysC)and albuminto-creatinine ratio(ACR)in the early diagnosis of diabetic nephropathy.Methods A total of 46 patients with simple diabetes admitted to the clinical Laboratory of Guanyuanxian Hospital of Traditional Chinese Medicine in Jiangsu Province from January 2021 to December 2022 were selected as observation group A,54 patients with diabetic ne⁃phropathy were selected as observation group B,and 56 patients who underwent physical examination in our hospital during the same period were selected as control group.The levels ofβ_(2)-MG,CysC and ACR were measured.To ana⁃lyze its diagnostic effect in early diabetic nephropathy.Results Theβ_(2)-MG,CysC and ACR in the observation group were(3.56±0.42)mg/L,(1.23±0.38)mg/L and(70.24±43.73)mg/g,which were higher than those in the control group(2.11±0.41)mg/L,(0.61±0.21)mg/L and(10.65±7.55)mg/g,and the differences were statistically significant(t=20.861,11.273,10.100,all P<0.05).The levels ofβ_(2)-MG,CysC and ACR in observation group B were higher than those in observation group A,and the differences were statistically significant(all P<0.05).The sensitivity,specificity and accuracy of combined detection were higher than that ofβ_(2)-MG,CysC and ACR single detection,and the differ⁃ences were statistically significant(all P<0.05).Conclusionβ_(2)-MG,CysC and ACR can be used as sensitive indica⁃tors in the diagnosis of early diabetic nephropathy patients,and have important significance in the diagnosis,treatment plan and prognosis assessment of patients.
作者
李继阳
余丽
张芹
LI Jiyang;YU Li;ZHANG Qin(Department of Clinical Laboratory,Guanyun County Hospital of Traditional Chinese Medicine,Guanyun,Jiangsu Province,222200 China)
出处
《系统医学》
2024年第2期54-57,共4页
Systems Medicine
