摘要
目的研究分析他克莫司与环磷酰胺合用对系统性红斑狼疮患者机体炎症及免疫指标的影响。方法随机选取2021年2月—2023年9月经仙游县医院收诊的系统性红斑狼疮患者60例为研究对象,结合随机数表法分为两组,每组30例。对照组单用环磷酰胺,观察组合用他克莫司与环磷酰胺,比较两组方案疗效、机体炎症指标、免疫指标及方案安全性。结果观察组方案疗效总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P=0.037)。治疗后,观察组各项机体炎症指标[白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-8(Interleukin-8,IL-8)以及肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)]水平均低于对照组,差异有统计学意义(P均<0.05);观察组各项免疫指标[免疫球蛋白A、G、M(Immunoglobulin A、G、M,IgA、IgG、IgM)]均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论他克莫司与环磷酰胺合用能够提升对系统性红斑狼疮患者的治疗效果,可更有效减轻机体炎症,调节机体免疫状况,并减少不良反应发生。
Objective To study and analysis the effects of tacrolimus combined with cyclophosphamide on inflammation and immune indexes in patients with systemic lupus erythematosus.Methods 60 patients with systemic lupus erythematosus admitted to Xianyou County General Hospital from February 2021 to September 2023 were randomly selected as the study objects and divided into two groups with 30 cases in each group by random number table method.The control group received cyclophosphamide alone,and the observation group received tacrolimus and cyclophosphamide.The efficacy,inflammatory indexes,immune indexes and safety of the two groups were compared.Results The total effective rate of observation group was 93.33%,which was higher than that of control group(73.33%),and the difference was statistically significant(χ^(2)=4.320,P=0.037).After treatment,The levels of various indicators of inflammation[Interleukin-6(IL-6),Interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)]in the observation group were lower than those of control group,and the differences were statistically significant(all P<0.05).All immune indexes[Immunoglobulin A,G,M(IgA,IgG,IgM)]in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Tacrolimus combined with cyclophosphamide can improve the therapeutic effect of systemic lupus erythematosus patients,can more effectively reduce inflammation,regulate the immune status of the body,and reduce the occurrence of adverse reactions.
作者
苏宇
张明谦
朱蓉蓉
SU Yu;ZHANG Mingqian;ZHU Rongrong(Department of Endocrinology,Xianyou County General Hospital,Putian,Fujian Province,351200 China)
出处
《中外医疗》
2024年第2期109-112,共4页
China & Foreign Medical Treatment
关键词
系统性红斑狼疮
他克莫司
环磷酰胺
机体炎症
免疫状况
Systemic lupus erythematosus
Tacrolimus
Cyclophosphamide
Body inflammation
Immune status
