摘要
膝关节骨性关节炎(knee osteoarthritis, KOA)作为一种严重损害生活质量的慢性残疾性疾病,患病后会使关节软骨退化同时引发软骨下骨重塑,导致膝关节疼痛、僵硬及功能受限,是常见的骨关节疾病之一。KOA作为炎症疾病,病因同时涉及到修复和降解机制。中性粒细胞作为强大的天然免疫效应细胞,可以精确调节血液和组织的功能,是关节损伤后首先进入滑膜的免疫细胞,是关节炎症和软骨破坏的重要因素,其活性是判断KOA进展的必要条件。本文聚焦KOA影响因素、其与中性粒细胞和巨噬细胞的关系、KOA的病理机制等方面,以期为KOA治疗提供参考。
Knee osteoarthritis(KOA),as a chronic disability disease that seriously damages the quality of life,will degrade articular cartilage and lead to subchondral bone remodeling,resulting in knee pain,stiffness and limited function.It is one of the most common bone and joint diseases.As an inflammatory disease,the etiology of KOA involves both repair and degradation mechanisms.Neutrophils,as powerful natural immune effector cells that can precisely regulate the function of blood and tissue.It is the first immune cells to enter the synovial membrane after joint injury and is an important factor in joint inflammation and cartilage destruction,and its activity is necessary for the progression of KOA.This article focus on KOA influencing factors,its relationship with neutrophils and macrophages,and the pathological mechanisms of KOA,so as to providing reference for KOA treatment.
作者
刘昕
郭佳军
马红娥
张文贤
LIU Xin;GUO Jiajun;MA Hong'e;ZHANG Wenxian(Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Geriatric Orthopedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《医学新知》
CAS
2024年第3期347-354,共8页
New Medicine
基金
国家自然科学基金地区科学基金项目(82060877)。
