摘要
目的分析甲状腺癌根治术患者麻醉诱导前予以咪达唑仑的临床效果。方法选取行甲状腺癌根治术的80例患者,按随机数字表法分为2组,各40例。对照组术中行常规麻醉诱导,观察组则于对照组基础上在麻醉诱导前予以咪达唑仑。对比2组麻醉效果、应激反应指标[肾上腺素(E)、去甲肾上腺素(NE)、白介素-10(IL-10)]、苏醒质量、麻醉药物用量、不良反应。结果麻醉诱导前(T0)、诱导后1 min(T1)、诱导后2 h(T5)、苏醒时(T6),2组脑电双频指数(BIS)相比,无统计学差异(P>0.05);诱导后3 min(T2)、气管插管时(T3)、诱导后1 h(T4),观察组BIS低于对照组,有统计学差异(P<0.05)。术前,2组E、NE、IL-10相比,无统计学差异(P>0.05);术后6 h,观察组E、NE、IL-10低于对照组,有统计学差异(P<0.05)。观察组唤醒睁眼、拔管时间短于对照组,丙泊酚与瑞芬太尼总用量少于对照组,且不良反应发生率低于对照组,有统计学差异(P<0.05)。结论甲状腺癌根治术的麻醉诱导前予以咪达唑仑可强化麻醉功效,控制应激反应,减少麻醉药物用量,提高苏醒质量,降低不良反应发生率,临床应用价值较高,可进行大力的推行。
Objective To analyze the clinical effect of midazolam administered before anesthesia induction in patients underwent radical thyroidectomy for thyroid cancer.Methods 80 patients who underwent radical thyroidectomy for thyroid cancer were selected and randomly divided into 2 groups,each with 40 cases.The control group received routine anesthesia induction during surgery,while the observation group received midazolam before anesthesia induction on the basis of the control group.Compare the anesthesia effect,stress response indicators[adrenaline(E),norepinephrine(NE),interleukin-10(IL-10)],awakening quality,anesthetic dosage,and adverse reactions between the 2 groups.Results There was no statistically significant difference in the bispectral index(BIS)between the 2 groups before anesthesia induction(T0),1 minute after induction(T1),2 hours after induction(T5),and at awakening(T6)(P>0.05);After 3 minutes of induction(T2),during tracheal intubation(T3),and 1 hour after induction(T4),the BIS of the observation group was lower than that of the control group,with statistical differences(P<0.05).Before surgery,there was no statistically significant difference in E,NE,and IL-10 between the 2 groups(P>0.05);At 6 hours after surgery,the E,NE,and IL-10 levels in the observation group were lower than those in the control group,with statistical differences(P<0.05).The observation group had shorter awakening,eye opening,and extubation times compared to the control group.The total dosage of propofol and remifentanil was lower than the control group,and the incidence of adverse reactions was lower than the control group,with a statistical difference(P<0.05).Conclusion Midazolam administered before anesthesia induction in thyroid cancer radical surgery can enhance anesthesia efficacy,control stress reactions,reduce anesthetic dosage,improve awakening quality,and reduce the incidence of adverse reactions.It has high clinical application value and can be vigorously promoted.
作者
李志刚
梁超
赵闯
LI Zhigang;LIANG Chao;ZHAO Chuang(General Hospital of Pingmei Shenma Medical Group,Pingdingshan,467000)
出处
《实用癌症杂志》
2024年第4期558-561,共4页
The Practical Journal of Cancer
关键词
甲状腺癌
麻醉诱导
咪达唑仑
应激反应
苏醒质量
不良反应
Thyroid cancer
Anesthesia induction
Midazolam
Stress response
Awakening quality
Adverse reactions
