摘要
目的探讨CD+T细胞及调节性T(Treg)细胞表面程序性死亡受体1(PD-1)水平与肺癌患者术后预后的关系。方法选取行肺癌根治术的肺癌患者126例,统计术后2年内预后不良发生率,并根据其预后情况将其分为良好组和不良组,单因素分析肺癌患者术后预后不良的影响因素,Logistic回归分析肺癌患者术后预后不良的影响因素,受试者工作特征曲线(ROC)分析CD+T细胞及Treg PD-1水平对肺癌患者术后预后的预测价值。结果两组肿瘤淋巴结转移(TNM)分期、CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)及Treg PD-1水平比较,均有显著差异(P<0.05);Logistic回归分析显示,CD3^(+)、CD3^(+)CD4^(+)是肺癌患者术后预后不良的独立保护因素,CD3^(+)CD8^(+)、Treg PD-1是肺癌患者术后预后不良的独立危险因素(P<0.05);ROC分析显示,CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)及Treg PD-1对肺癌患者预后预测的最佳截断点分别为53.52%、27.94%、27.96%、21.36%,曲线下面积(AUC)分别为0.731、0.810、0.691、0.969。结论肺癌患者中CD3^(+)和CD3^(+)CD4^(+)呈低表达、CD3^(+)CD8^(+)呈高表达及Treg PD-1呈高表达与近期预后不良有关。
Objective To investigate the relationship between the level of programmed death receptor-1(PD-1)on the surface of CD+T cells and regulatory T(Treg)cells and the prognosis of lung cancer patients after operation.Methods 126 patients with lung cancer who underwent radical resection were selected.The incidence of poor prognosis within 2 years after operation was counted and divided into good group and bad group according to the prognosis.Univariate analysis of the factors influencing the poor prognosis of lung cancer patients after surgery.Logistic regression analysis was used to analyze the influencing factors of poor prognosis of lung cancer patients after operation.The predictive value of the level of CD+T cells and Treg PD-1 on the prognosis of lung cancer patients after surgery was analyzed by the receiver operating characteristic curve(ROC).Results There were significant differences in tumor lymph node metastasis(TNM)stage,CD3^(+),CD3^(+)CD4^(+),CD3^(+)CD8^(+)and Treg PD-1 levels between the two groups(P<0.05).Logistic regression analysis showed that low expression of CD3^(+)and CD3^(+)CD4^(+),high expression of CD3^(+)CD8^(+)and high expression of Treg PD-1 were independent risk factors for poor prognosis of lung cancer patients after surgery(P<0.05).ROC analysis showed that the best cutoff points of CD3^(+),CD3^(+)CD4^(+),CD3^(+)CD8^(+)and Treg PD-1 for predicting the prognosis of lung cancer patients were 53.52%,27.94%,27.96%and 21.36%.And the area under the curve(AUC)was 0.731,0.810,0.691 and 0.969.Conclusion The low expression of CD3^(+)and CD3^(+)CD4^(+),the high expression of CD3^(+)CD8^(+)and the high expression of Treg PD-1 in lung cancer patients are associated with poor short-term prognosis.
作者
李军伟
王瑞
程再轩
LI Junwei;WANG Rui;CHENG Zaixuan(Xinyang Central Hospital,Xinyang,464000)
出处
《实用癌症杂志》
2024年第4期607-611,共5页
The Practical Journal of Cancer
关键词
肺癌
调节性T细胞
程序性死亡受体1
预后
Lung cancer
Regulatory T cells
Programmed death receptor-1
Prognosis
