摘要
目的探究肝动脉介入化疗栓塞术对原发性肝癌术后患者的疗效。方法选择100例原发性肝癌患者作为观察对象,按随机数字表法分成2组,各50例。两组均于腹腔镜引导行肿瘤切除术,研究组在术后7 d辅以肝动脉介入化疗栓塞术治疗,治疗后随访2年。对比治疗前后两组肝功能[谷草转氨酶(AST)、总胆红素(TBIL)及谷丙转氨酶(ALT)]、血清肿瘤标志物[糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)及磷脂酰肌醇蛋白聚糖-3(GPC3)]水平、生存质量[生命质量测定量表(QOL-LC)],统计两组术后复发率及生存率。结果与治疗前对比,两组治疗后7 d的血清AST、TBIL、ALT水平均增高,且研究组较对照组更高,差异有统计学意义(P<0.05);与治疗前对比,两组治疗后1个月血清CA19-9、AFP、GPC3水平均降低,且研究组较对照组更低,差异有统计学意义(P<0.05);与治疗前对比,治疗后1个月两组QOL-LC评分均增高,且研究组[(185.74±12.34)分]较对照组[(164.30±11.55)分]更高,差异有统计学意义(P<0.05);研究组治疗后2年复发率为26.00%(13/50),低于对照组的50.00%(25/50),生存率为84.00%(42/50),高于对照组的64.00%(32/50),差异有统计学意义(P<0.05)。结论肝动脉介入化疗栓塞术辅助肿瘤切除术治疗原发性肝癌效果更佳,可有效降低血清肿瘤标志物表达水平,改善肺功能及生存质量,提升临床生存率,利于预后。
Objective To explore the therapeutic effect of hepatic artery interventional chemotherapy embolization on postoperative patients with primary liver cancer.Methods 100 patients with primary liver cancer were selected as the observation subjects and divided into 2 groups using a random number table method,with 50 patients in each group.Laparoscopic guided tumor resection was performed in both groups.At the same time,the study group was treated with hepatic artery interventional chemotherapy and embolization 7 days after surgery.The follow-up was 2 years.The levels of liver function indicators[AST,TBIL and ALT],serum tumor markers[carbohydrate antigen 19-9(CA19-9),alpha fetoprotein(AFP)and phosphatidylinositol proteoglycan-3(GPC3)],and quality of life[QOL-LC]were compared between the 2 groups before and after treatment,and the postoperative recurrence rate and survival rate were calculated.Results Compared with that before treatment,the levels of AST,TBIL and ALT in serum of the 2 groups increased 7 days after treatment,and the levels of AST,TBIL and ALT in the study group were higher than those in the control group,with a statistically significant difference(P<0.05);Compared with that before treatment,the levels of serum CA19-9,AFP and GPC3 in the two groups decreased one month after treatment,and the levels in the study group were lower than those in the control group,with a statistically significant difference(P<0.05);Compared with that before treatment,the QOL-LC scores of patients in the two groups increased one month after treatment,and the score of the study group(185.74±12.34)was higher than that of the control group(164.30±11.55),with a statistically significant difference(P<0.05);2 year recurrence rate after treatment in the study group was 26.00%(13/50),which was lower than 50.00%(25/50)in the control group,and the survival rate was 84.00%(42/50),which was higher than 64.00%(32/50)in the control group.The difference was statistically significant(P<0.05).Conclusion Hepatic artery interventional chemoembolization assisted with tumor resection is more effective in the treatment of primary liver cancer,which can effectively reduce the expression level of serum tumor markers,improve lung function and quality of life,improve the clinical survival rate,and benefit the prognosis.
作者
李娟
田海龙
朱涛
王岳
李晓
LI Juan;TIAN Hailong;ZHU Tao(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第4期644-647,共4页
The Practical Journal of Cancer
关键词
原发性肝癌
肿瘤切除术
肝动脉介入化疗栓塞术
肝功能
血清肿瘤标志物
复发率
生存率
Primary liver cancer
Tumor resection
Transcatheter arterial chemoembolization
Liver function
Serum tumor markers
Recurrence rate
Survival rate
