摘要
目的 探讨新诊断2型糖尿病(Type 2 Diabetes Mellitus, T2DM)患者不同糖化血红蛋白(Glycosylated Hemoglobin A1c, HbA1c)水平与临床资料、胰腺脂肪沉积的相关性。方法 回顾性分析2022年1—12月北京丰台银铃中医医院综合内科病区收治的279例新诊断T2DM患者的临床资料,根据HbA1c水平分为6.0%≤HbA1c<7.0%组91例、7.0%≤HbA1c<9.0%组90例及HbA1c≥9.0%组98例,采用磁共振检测各组胰腺脂肪沉积程度。采用Pearson相关分析HbA1c与其他指标的相关性。结果 3组空腹血糖(Fasting Plasma Glucose,FPG)、餐后2 h血糖(2-hour Postprandial Blood Glucose, 2 hPG)、空腹胰岛素(Fasting Insulin, FINS)、三酰甘油(Triglyceride, TG)、低密度脂蛋白胆固醇(Low-density Lipoprotein Cholesterol, LDL-C)、高密度脂蛋白胆固醇(High-density Lipoprotein Cholesterol, HDL-C)、胰岛素抵抗指数(Insulin Resistance Index, HOMA-IR)、胰岛素分泌指数(Insulin Secretion Index, HOMA-β)及胰腺脂肪分数(Pancreatic Fat Fraction, PFF)比较,差异有统计学意义(P均<0.05)。Pearson相关分析显示,HbA1c与FPG、2 hPG、TG、LDL-C、HOMA-IR、PFF水平呈正相关(r=0.605、0.574、0.536、0.122、0.780、0.672,P均<0.05),与FINS、HDL-C、HOMA-β呈负相关(r=-0.232、-0.265、-0.731,P均<0.001)。结论 随着HbA1c水平升高,新诊断T2DM患者胰腺脂肪沉积程度越严重,其可能与糖代谢异常、血脂紊乱及胰岛素抵抗有关。
Objective To investigate the correlation of different Glycosylated Hemoglobin A1c(HbA1c)levels with clinical data and pancreatic fat deposition in newly diagnosed patients with Type 2 Diabetes Mellitus(T2DM).Methods The clinical data of 279 newly diagnosed T2DM patients admitted to the comprehensive internal medicine ward of Fengtai Yinling Hospital of Traditional Chinese Medicine in Beijing from January to December 2022 were ret-rospectively analyzed,and divided into the 6.0%≤HbA1c<7.0%group with 91 cases,the 7.0%≤HbA1c<9.0%group with 90 cases,and the HbA1c≥9.0%group with 98 cases according to the HbA1c level.The degree of pancreatic fat deposition in each group was detected by magnetic resonance.Pearson correlation was used to analyze the correlation in HbA1c and other indexes.Results Fasting Plasma Glucose(FPG),2-hour Postprandial Blood Glucose(2 hPG),Fasting Insulin(FINS),Triglyceride(TG),Low-density Lipoprotein Cholesterol(LDL-C),High-density Lipoprotein Cholesterol(HDL-C),Insulin Resistance Index(HOMA-IR),Insulin Secretion Index(HOMA-β)and Pancreatic Fat Fraction(PFF)were compared between three groups,the differences were statistically significant(all P<0.05).Pearson correlation analysis showed that HbA1c was positively correlated with levels of FPG,2 hPG,TG,LDL-C,HOMA-IR and PFF(r=0.605,0.574,0.536,0.122,0.780,0.672,all P<0.05),negatively correlated with FINS,HDL-C and HOMA-β(r=-0.232,-0.265,-0.731,all P<0.001).Conclusion With the increase of HbA1c level,the degree of pan-creatic fat deposition in newly diagnosed T2DM patients becomes more serious,which may be related to abnormal glu-cose metabolism,lipid disorders and insulin resistance.
作者
田琴琴
李静
董洪海
侯海华
TIAN Qinqin;LI Jing;DONG Honghai;HOU Haihua(Department of General Internal Medicine,Beijing Fengtai Yinling Hospital of Traditional Chinese Medicine,Beijing,)
出处
《糖尿病新世界》
2024年第2期8-11,共4页
Diabetes New World Magazine
关键词
糖化血红蛋白
新诊断
2型糖尿病
胰腺脂肪沉积
Glycosylated hemoglobin
New diagnosis
Type 2 diabetes
Pancreatic fat deposition
