摘要
目的 评估血浆D二聚体水平的检测应用在2型糖尿病肾病患者中的作用和临床意义。方法 回顾性分析厦门市中医院在2021年1月—2022年1月期间收治的120例2型糖尿病肾病患者的全部病历资料,按照尿微量白蛋白排泄率(Urinary Albumin Ejection Rate, UACR)予以分组,分为正常蛋白尿组(n=40,UACR<20μg/min)、微量蛋白尿组(n=40,UACR在20~200μg/min之间)、大量尿蛋白组(n=40,UACR>200μg/min),每组40例。选取同期健康体检者40例作为对照组,全部均接受血浆D二聚体水平检查,分析效果与临床意义。结果 大量尿蛋白组的D二聚体高于微量蛋白尿组、正常蛋白尿组、对照组,且4组D二聚体水平对比,差异有统计学意义(P均<0.05)。血浆D二聚体与2型糖尿病肾病患者蛋白尿水平呈正相关(r=0.253)。结论 2型糖尿病肾病患者蛋白尿水平越高,血浆D二聚体水平越高,血浆D二聚体可以作为检测糖尿病肾病患者疾病进展的重要参考指标。
Objective To evaluate the role and clinical significance of plasma D-dimer level detection in patients with type 2 diabetic nephropathy.Methods All the medical records of 120 patients with type 2 diabetic nephropathy admitted to Xiamen Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were retrospectively analyzed.According to the urinary albumin ejection rate(UACR),the patients were divided into normal albuminuria group(n=40,UACR<20μg/min),microalbuminuria group(n=40,UACR>200μg/min)and large urinary protein group(n=40,UACR>200μg/min),with 40 cases in each group.40 healthy subjects in the same period were selected as the control group,and all of them were examined by plasma D-dimer level to analyze the effect and clinical significance.Results The level of D-dimer in the large urinary protein group was higher than that in the microalbuminuria group,the normal albuminuria group and the control group,and comparison of D-dimer levels in 4 groups the differences were statistically significant(all P<0.05).Plasma D-dimer was positively correlated with albuminuria level in type 2 diabetic nephropathy patients(r=0.253).Conclusion The higher the level of proteinuria in type 2 diabetic nephropa-thy patients,the higher the level of plasma D-dimer,which can be used as an important reference index to detect the disease progression in diabetic nephropathy patients.
作者
陈君颖
游含宇
叶玉琼
CHEN Junying;YOU Hanyu;YE Yuqiong(Department of Laboratory,Xiamen Hospital of Traditional Chinese Medicine,Xiamen,Fujian Province,361009 China)
出处
《糖尿病新世界》
2024年第2期52-54,64,共4页
Diabetes New World Magazine
关键词
血浆D二聚体水平
2型糖尿病肾病
临床意义
Plasma D-dimer level
Type 2 diabetic nephropathy
Clinical significance
